肝脏良恶性病变AgNORs计数研究及与乙型肝炎病毒的关系  

A Study of AgNORs in Benign and Malignant Liver Diseases and the Relationship Between AgNORs Numbers and Hepatitis B Virus

作　　者：叶洪涛 侯巧燕 凌霞 陈峰 

出　　处：《华夏医学》1994年第1期11-13,共3页Acta Medicinae Sinica

摘　　要：对１３７例肝脏良恶性病变分别进行嗜银蛋白核仁形成区（ＡｇＮＯＲｓ）定量计数及其乙型肝炎病毒（ＨＢＶ）表面抗原（ＨＢｓＡｇ）的检测。结果显示：肝细胞癌（ＨＣＣ）、肝硬化和不典型增生肝细胞（ＬＣＤ）的ＡｇＮＯＲｓ数量均明显高于正常肝细胞，慢性持续性肝炎和慢性活动性肝炎（ｐ＜０．００１），ＨＣＣ与肝硬化之间差异也非常显著（ｐ＜０．００１），提示ＡｇＮＯＲｓ定量对鉴别肝脏良恶性病变有重要参考价值，而有无ＨＢＶ感染与ＡｇＮＯＲｓ定量无明显关系，故可能ＨＢＶ不影响核仁形成区而致癌变。Using a silver staining technique ,AgNORs was quantitatively studied in paraffin secions of 137 autopsy and biopsy cases of benign and malignant liver diseases. Hepatitis B surface antigens(HBsAg)were detected by immunohistochemical method. A significant difference was found between the numbers of AgNORs in the nuclei of hepatocellular carcinoma(HCC),liver cell dysplasia(LCD),cirrhosis and hormal liver. It is suggested that this method is applicable in the classification of benign and malignant liver diseases. The numbers of AgNORs were not. Associated with HBsAg infection.

关 键 词：核仁形成区 肝脏 乙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤]