孕妇禁忌中药(商陆)抗早孕作用的实验研究  

Experimental investigation on An-ti-early Pregnancy action of Chinese Medicinal Herb (Phytolacca acinosa Roxb) Contraindicated for Pregnant Women

作　　者：李成林[1] 王建军[1] 郝奋[1] 张佩林[1] 

机构地区：[1]包头医学院,014010

出　　处：《中国优生与遗传杂志》1993年第4期17-18,137,共3页Chinese Journal of Birth Health & Heredity

摘　　要：本项研究证实,用半致死量的1/6的商陆煎剂灌胃,导致38只孕早期大鼠胚胎在三天内全部死亡,并于灌药后一周,基本上已完全消失,抗早孕率达100％。为进一步了解商陆煎剂的毒性,以健康未孕雌鼠作对照,灌药后杀死,取其主要脏器和内生殖器官,经病理组织学切片检查,未发现任何异常改变。另对第一批9只实验鼠,在灌药后49天,再次进行交配,又全部怀孕。可见商陆煎剂灌鼠虽可杀死胚胎,但对子宫和卵巢等器官的结构和功能,并未造成任何损伤,上述实验结果表明,商陆煎剂有可能成为安全、简便、高效且易被接受的一种抗早孕药物。The present study showed that perfusing the stomach with 1/6 LD50 Phytolacca acinosa Roxb decoction had caused the death of 33 rat's embryo in early pregnancy within three days. One week after the perfusion,the embryos were completely absorbed and anti-early pregnancy rate was 100%. To further understand the toxicity of Phytolacca acinosa Roxb decoction, healthy and non-pregnant female rats were used as control, when they were perfused with the decoction and then killed, their major organs and internal genital organs were taken for histopathological section study and no abnormal changs were found. Another nine experimented rats of the first group, all became pregnant when they copulated .Though 49 days after the perfusion, Phytolacca acinosa Roxb decoction killed the embryos, it didn't do any damage to the structure and function of uterus,ovary and other organs. The result of the above experiment suggests that Phyti-lacca acinosa Roxb decoction may become a safe convienient, efficient and acceptable anti early pregnancy drug.

关 键 词：孕妇禁忌中药 商陆 抗早孕 

分 类 号：R394[医药卫生—医学遗传学]