注射甘油对兔下齿槽神经的影响——形态学及电生理学研究  

Effect of anhydrous glycerol injection into the mental foramen of rabbit on inferior nerve: An experimental study

作　　者：王友山[1] 东耀峻[2] 苏倩倩[2] 

机构地区：[1]汕头市中心医院口腔科,515031 [2]湖北医学院口腔系

出　　处：《上海口腔医学》1992年第2期86-90,131,共6页Shanghai Journal of Stomatology

摘　　要：本实验于兔下颌颏孔内注射无水甘油,通过电生理学及形态学方法,观察注射后下齿槽神经的变化情况。结果显示注射无水甘油后仅使部分神经纤维受损害,其电生理学改变为神经干复合动作电位的潜伏期延长、振幅减小;形态学改变主要为髓鞘肿胀、断裂,轴索变形、溶解。注射无水甘油后第1周电生理学及形态学改变最明显,第5周时可见再生迹象,第16周时基本恢复正常。In this experiment, anhydrous glycerol was injected into the mental foramen of rabbits to determine neurolytic effects on the peripheral trigeminal nerve by electrophysi-ologic and morphologic methods. The rabbits underwent unilateral injection of anhydrous glycerol and the control side was injected with normal saline. The results show that partial fibers are affected (myelinated and unmyelinated fibers at random). Glycerol injection increased the average latencies and reduced the average amplitudes of compound action potentials. Morphologic examination disclosed myelin swelling, disinter-gration and axonal shrinking, axonolysis. One week after the injection, eletrophysio-logic and morphologic changes were most severe and signs of regeneration were noted in the fifth week. By 16 weeks after injection, the nerve fibers appeared almost normal.

关 键 词：甘油 三叉神经痛 下齿槽神经 

分 类 号：R78[医药卫生—口腔医学]