早期干预改善缺氧缺血性脑病患儿智力发育  

Improvement of early intervention on intellectual development of neonates with hypoxic ischemic encephalopathy

作　　者：柯尊宇[1] 明萌[2] 梁松[3] 肖玉[2] 

机构地区：[1]郧阳医学院附属人民医院心理咨询中心,湖北省十堰市442000 [2]郧阳医学院附属太和医院儿科,湖北省十堰市442000 [3]东风公司花果医院小儿弱智脑瘫治疗中心,湖北省十堰市442049

出　　处：《中国临床康复》2004年第18期3565-3567,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨早期干预对改善缺氧缺血性脑病(hypoxicischemicen-cephalopathy,HIE)患儿智力发育的作用。方法:将98例中重度HIE患儿分为干预组48例,对照组50例,干预组自新生儿期开始干预治疗至2岁,所有病例均于1,2岁时进行智能发育检测。结果:干预组在1,2岁时智力发育指数(mentaldevelopmentalindex,MDI)和心理运动发育指数(psycho-motordevelopmentalindex,PDI)明显高于对照组,差异有显著性(t=4.93;t=4.269和t=2.99;t=2.875,P均<0.01)。干预组有4例发生后遗症,康复率为92%,而对照组有13例发生后遗症,康复率仅74%;两组患儿预后差异有显著性意义(χ2=4.17,P<0.05)。结论:早期干预可促进HIE患儿智力发育,预防及降低HIE后遗症的发生。AIM:To investigate the effect of early intervention for improving the intellectual development of neonates with hypoxic ischemic encephalopathy(HIE). METHODS:A total of 98 neonates with moderate or severe HIE were divided into two groups:48 in early intervention group and 50 in control group.Early intervention was performed in the early intervention group from the birth to two years old,and intellectual development was examined at the age of one or two years old in all neonates. RESULTS:At the age of one or two,the mental developmental index and psycho motor developmental index in the early intervention group were remarkably higher than those in the control group,and there was significant differences between the two groups(t=4.93;t=4.269 and t=2.99;t=2.875,P< 0.01).Sequelas appeared in four neonates and the recovery rate of neonates in the early intervention group was 92%in comparison with 74%the in the control group,which showed significant difference(χ2 =4.17,P< 0.05). CONCLUSION:Early intervention can promote the intellectual development of neonates with HIE,and furthermore,it benefits to the prevention of HIE sequelae.

关 键 词：脑缺血/康复 脑缺氧/康复 神经系统/生长和发育 智力 

分 类 号：R742.3[医药卫生—神经病学与精神病学]