心理应激对不同行为类型者血浆环核苷酸含量的影响(英文)  

Effect of psychological stress on the content of plasma cyclic nucleotide in individuals of different behavior types

作　　者：张爱华[1] 周力[1] 李佩贤[1] 徐丽华[1] 王力[1] 

机构地区：[1]潍坊医学院诊断学教研室,山东省潍坊市261042

出　　处：《中国临床康复》2004年第18期3658-3659,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:在分子生物学基础上探讨冠心病发病中介机制研究的较少,而从这一水平上研究冠心病的发病机制十分有利于其预防和控制。目的:了解不同行为类型应激者血浆环核苷酸变化,为探讨心理行为因素引起冠心病的中介机制的研究提供前瞻性资料。设计:前瞻性研究。地点、对象和方法:通过问卷从300名志愿者中随机筛选出A型行为与B型行为高考生各19人为研究对象,考前80d和考前1d分别于16:30～17:00抽取潍坊一中A、B型行为学生静脉血,检测血浆环核苷酸含量,观察心理应激(应激源为高考)对不同行为类型者血浆环核苷酸含量的影响。主要观察指标:应激前后血浆环核苷酸含量。结果:应激前A型行为高考生的血浆环一磷酸腺苷(cAMP)含量犤(15.46±3.56)nmol/L犦显著高于B型行为的高考生犤(12.09±2.78)nmol/L犦,差异有非常显著性意义(t=3.25,P<0.01);应激后,A型行为高考生的cAMP,cAMP/环一磷酸鸟苷(cGMP)降低犤分别为(10.911±3.950),(5.526±1.488)nmol/L犦,与应激前比较,差异有显著性意义(t=12.25,8.14,P<0.001),cGMP升高了犤(2.962±0.764)nmol/L犦(t=-9.06,P<0.001);B型行为高考生的cAMP,cAMP/cGMP降低犤分别为(7.379±1.762),(3.677±1.488)nmol/L犦(t=7.42,7.56,P<0.001);cGMP升高了犤(2.280±0.685)nmol/L犦(t=-7.52。BACKGROUND:Research on coronary heart disease(CHD) mediator based on molecular biology is scarce,however,it is very helpful for the prevention and control of CHD on that level. OBJECTIVE:To find out the changes of plasma cyclic nucleotide in individuals of different behavior types so as to provide prospective data for the research of mediator of psychological factors inducing CHD. DESIGN:A prospective study. SETTING,PARTICIPANTS and INTERVENTION:Type A and B behaviour examinees,19 respectively,were selected at random from 300 volunteers by questionnaire.Their venous bloods were collected at 16:30 to 17: 00 80 days and 1 hour before examination respectively in Weifang First Middle School.Content of plasma cyclic nucleotide were assayed to observe the effect of psychological stress(university entrance examination is the stress origin) on individuals in different behavior types. MAIN OUTCOME MEASURES:Content of plasma cyclic nucleotide before and after stress respectively. RESULTS:Before the stress,content of plasma cyclic adenosine monophosphate(cAMP)[(15.46±3.56)nmol/L]of type A was significantly higher than type B[(12.09±2.78)nmol/L],and this distinction had quite remarkable meanings(t=3.25,P< 0.01).After the stress,the plasma cAMP and cAMP/cGMP content in type A decreased compared with that before stress[(10.911±3.950),(5.526±1.488)nmol/L respectively],and the differeces were significant(t=12.25,8.14,P< 0.001),meanwhile,cGMP increased[(2.962±0.764)nmol/L](t=-9.06,P< 0.001); the plasma cAMP and cAMP/cGMP in type B decreased[(7.379±1.762),(3.677±1.488) nmol/L](t=7.42,7.56,P< 0.001), while cGMP increased[(2.280±0.685) nmol/L](t=-7.52,P< 0.001).The decrease range of cAMP and Camp/cGMP in type A were significantly higher than that in type B(t=3.56,3.83,P< 0.001). CONCLUSION:Effect of stress caused by college entrance examination on the content of plasma cyclic nucleotide in the type A students is significantly greater than that in the type B students.

关 键 词：应激 心理学 核苷酸类 环/血液 冠状动脉疾病/病因学 

分 类 号：R749[医药卫生—神经病学与精神病学]