6-硝基吲哚合并BSO的放射增敏作用初探  

PREL IMINARY STUDY ON THE EFFECT OF 6-NITRO-INDAZOLE COMBINED WITH BSO IN VITRO CELLS

作　　者：杨志文[1] 李政[1] 沈瑜[1] 糜福顺[1] 

机构地区：[1]中国医学科学院肿瘤研究所

出　　处：《中华放射肿瘤学杂志》1992年第4期41-42,74,共3页Chinese Journal of Radiation Oncology

摘　　要：6-硝基吲唑对乏氧细胞有较强的增敏作用,但对正常有氧细胞也有一定的毒性。初步研究降低6-硝基吲唑浓度及合并BSO的离体细胞放射增敏效应。结果表明:BSO可增强6-硝基吲唑的放射增敏效应,单纯用6-硝基吲唑的增敏比为1.73(2mM);用BSO合并6-硝基吲唑的增敏比以Do计为l.83;以Dq计则单纯用6-硝基吲唑及合并BSO的增敏比值分别为1.90和2.95。6-Nitro-Indazole (DEAENI) shows high radiosensitizing effect on hypoxic HeLa-S3 cells in vitro. But it also has some toxic effects on the normal cells. By diluting DEAENI and combining it with BSO, we studied its in vitro effect. The results showed that the radiosensitizing effect of DEAENI was enhanced by BSO with a SER of 1.73 (2mM).When the cells were pretreated with BSO, the SER of DEAENI alone and DEAENI plus BSO at Do level were 1.73 and 1.83. Calculated at Dq level, the SER were 1.90 and 2.95, respectively. The authors believe that combination of DEAENI with BSO may supplement DEAENI which only shows strong radiosensitizing effect in high dose irradiation. This combination could lower the concentration of DEAENI used.

关 键 词：6-硝基吲唑合并BSO 放射增敏 

分 类 号：R73[医药卫生—肿瘤]