鼻咽癌低氧放疗近期疗效  

IMMEDIATE RESPONSE IN HYPOXY RADIOTHERAPY OF NASOPHARYNGEAL CARCINOMA(NPC)

作　　者：吴德华[1] 陈永清[1] 阁卫平 杨雄浩[1] 边建明 张军[1] 武华坪[1] 徐艳丽 陈红文[1] 许志新[1] 

机构地区：[1]第一军医大学南方医院

出　　处：《中华放射肿瘤学杂志》1992年第2期9-10,66,共3页Chinese Journal of Radiation Oncology

摘　　要：1990年3月至1991年8月,40例鼻咽癌随机分组为低氧照射组和照射组各20例。两组鼻咽与颈部照射D_T68～72Gy,5次/周,2Gy/次。低氧组在吸入10.5％氧气2分钟后照射,3分钟结束。两组肿瘤消退剂量、疗后复发、白细胞变化无差异,但出现口干、咽癌距首次放疗时间和口腔粘膜反应,低氧组比对照组晚,程度轻,说明低氧放疗对口腔粘膜有保护作用。From March 1990 to August 1991, 40 NPC patients were randomized into hypoxyradiotherapy group (20 patients) and radiotherapy alone group (20 patients). For radiotherapy, 68-72 Gy was delivered to the nasopharynx and the bilateral neck regions, 2 Gy per session, 5 sessions per week. For hypoxia, 10.5% oxygen inhalation was started before and lasted to 3 minutes after radiation. The results showed the complete response, recurrence and WBC change were similar in the two groups. Yet, xerostomia, sore throat, mucosal reaction appeared late and were milder in the hypoxyradiotherapy group. The authors believe that hypoxic inhalation may be protective to the oral structures.

关 键 词：鼻咽癌 低氧放疗 

分 类 号：R73[医药卫生—肿瘤]