COMPARATIVE STUDY ON THE INHIBITORY EFFECT OF GREEN TEA, COFFEE AND LEVAMISOLE ON THE HEPATOCARCINOGENIC ACTION OF DIETHYLNITROSAMINE  

作　　者：李瑗 严瑞琪 覃国忠 段小娴 覃柳亮 

机构地区：[1]Department of Pathology, Guangn Cancer Institute, Nanning

出　　处：《Chinese Journal of Cancer Research》1992年第2期9-12,共4页中国癌症研究（英文版）

摘　　要：The present study aimed at clarifying whether Chinese green tea, coffee and levamisole (LMS) have similar Inhibitory effect on hepatocarclnogenesis induced by diethylnltrosamine (DEN) as they had been proved in our previous aflatoxin B1 (AFB1) experiments. Male Wistar rates were divided into control (A), green tea (B), coffee (C) and levamisole (D) groups. All rats received the same basic DEN treatment according to the program originally designed by Solt and Farber. During the two weeks before and one week after i. p. injection of DEN, the group B, C and D were given 2. 5% green tea, 5% coffee and 0. 1% LMS diet, respectively. The results demonstrated that coffee, LMS and , in particular,green tea showed Inhibitory effect against DEN-induced hepatocarcinogenesis, indicating that green tea can be used as chemopreventive agent for DEN-, as well as for AFB1-induced hepatocarcinogenesis.The present study aimed at clarifying whether Chinese green tea, coffee and levamisole (LMS) have similar Inhibitory effect on hepatocarclnogenesis induced by diethylnltrosamine (DEN) as they had been proved in our previous aflatoxin B1 (AFB1) experiments. Male Wistar rates were divided into control (A), green tea (B), coffee (C) and levamisole (D) groups. All rats received the same basic DEN treatment according to the program originally designed by Solt and Farber. During the two weeks before and one week after i. p. injection of DEN, the group B, C and D were given 2. 5% green tea, 5% coffee and 0. 1% LMS diet, respectively. The results demonstrated that coffee, LMS and , in particular,green tea showed Inhibitory effect against DEN-induced hepatocarcinogenesis, indicating that green tea can be used as chemopreventive agent for DEN-, as well as for AFB1-induced hepatocarcinogenesis.

关 键 词：COMPARATIVE STUDY ON THE INHIBITORY EFFECT OF GREEN TEA COFFEE AND LEVAMISOLE ON THE HEPATOCARCINOGENIC ACTION OF DIETHYLNITROSAMINE 

分 类 号：R73[医药卫生—肿瘤]