软脑膜下多处横切术治疗顽固性功能区癫痫的实验研究  

Experimental Study of Multiple Subpial Transection for the Treatment of Intractable Focal Epilepsy

作　　者：刘宗惠[1] 赵全军[1] 李士月[1] 田增民[1] 陈小菡[1] 康桂泉[1] 崔月汉[1] 冯海莉[1] 

机构地区：[1]海军总医院神经外科

出　　处：《海军医学杂志》1992年第4期334-338,共5页Journal of Navy Medicine

摘　　要：本文以家兔为实验动物,随机分为横切与对照2组(每组各6只),横切组家兔在实验侧皮层按2mm间距进行软脑膜下横切,对照组只打开实验侧硬膜而不做皮层横切。术后均以实验侧皮层局部注射150U青霉素的方法诱发癫痫。结果发现:对照组均有抽搐发生,脑电图表现为以注药皮层为主的单发或连续性高幅棘尖波,并波及其他导联,而横切组仅在注药皮层可见单发低幅尖波,偶呈连续出现,不波及其他导联,且无任何抽搐表现。两组动物术后均无明显功能损害。病理检查发现:对照组双侧皮层、海马及小脑均有神经细胞乏氧性改变,而横切组仅在注药区很小范围内出现神经细胞损害,其余结构正常。该实验从行为、电生理及病理三方面证实软脑膜下多处横切术的机理和疗效,为该术式的临床应用提供了可靠依据。Rabbits were divided into two groups:multiple subpial transected and nontransected (six for each) and were both intracortically injected with 150U penicillin to induce epilesy. No seizure occurred in the transected group,but in the nontransected group convulsion occurred Frequently. No functional impairment was found in the transected rabbits. Results of symptomatological, physiological and pathological examinations indicated the MST had a good effect on seizure control.

关 键 词：功能区癫痫灶 软脑膜下多处横切术 

分 类 号：R[医药卫生]