SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE  

作　　者：刘克良 何炳林 萧绍博 夏启明 方溪 王忠义 

机构地区：[1]Institute of Pharmacology and Toxicology,PO Box130 [2]Institute of Polymer Chemistry, Nankai University [3]Tianjin Municipal Research Institute for Family Planning, Tianjin Medical College

出　　处：《Science China Chemistry》1991年第2期201-208,共8页中国科学（化学英文版）

基　　金：This work was supported in part by grants from United Nations Fund for Population Activities (UNFPA) and State Family Planning Commission of China.

摘　　要：<正> Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.

关 键 词：NEW ANTAGONISTS of LHRH antiovulatoty activity SOLID-PHASE SYNTHESIS of peptides 

分 类 号：O6[理学—化学]