ANTAGONISTS

作品数：143被引量：505H指数：12
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Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes
《Journal of Animal Science and Biotechnology》2024年第4期1567-1577,共11页Laman K.Mamedova Kirby C.Krogstad Paiton O.McDonald Laxman Pokhrel Duy H.Hua Evan C.Titgemeyer Barry J.Bradford 
the National Institutes of Health, National Institute of General Medical Sciences (R01 GM128659) for financial support;The Attune Cytpix, located in the MSU Flow Cytometry Core Facility, is supported by the Equipment Grants Program, award #2022-70410-38419, from the U.S. Department of Agriculture (USDA), National Institute of Food and Agriculture (NIFA)。
Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid(BHBA;the primary blood ketone)...
关键词：Flow cytometry GPR109A HM74A KETOSIS 
Role of CD36 in central nervous system diseases被引量：1
《Neural Regeneration Research》2024年第3期512-518,共7页Min Feng Qiang Zhou Huimin Xie Chang Liu Mengru Zheng Shuyu Zhang Songlin Zhou Jian Zhao 
supported by the National Major Project of Research and Development,No.2022YFA1105500(to SZ);the National Natural Science Foundation of China,No.81870975(to SZ);Innovation Program for Graduate Students in Jiangsu Province of China,No.KYCX223335(to MZ)。
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.CD36 was recently found to be widely expresse...
关键词：animal experiments ANTAGONISTS CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate 
Development of abscisic acid receptor agonists/antagonists and their application prospect in agriculture:An overview
《Advanced Agrochem》2024年第1期9-25,共17页Xianjun Tang Xiaobin Li Zhaohai Qin 
supported by the National Natural Science Foundation of China(No.22077136).
Abscisic acid(ABA),a plant hormone,is crucial for regulating various physiological and developmental processes in plants,including adaptation to biotic and abiotic stresses.Recent advancements have significantly contr...
关键词：Abscisic acid(ABA) ABA receptors Receptor agonists Receptor antagonists 
Antiviral factors and their counteraction by HIV-1: many uncovered and more to be discovered
《Journal of Molecular Cell Biology》2024年第2期1-10,共10页Dorota Kmiec Frank Kirchhoff 
supported by the Deutsche Forschungsgemeinschaft(CRC 1279);supported by a‘Bausteinprogramm’grant from Ulm University Medical Center,Else Kröner Fresenius Stiftung(2022_EKEA.47);European Union's Horizon 2020 Marie Sklodowska-Curie program(no.101062524).
Extensive studies on HIV-1 have led to the discovery of a variety of structurally and functionally diverse innate defense factors that target various steps of the retroviral replication cycle.Some of them,such as APOB...
关键词：HIV-1 restriction factors viral antagonists interferon-stimulated genes antiviral factors 
Advances in the research and application of neurokinin-1 receptor antagonists被引量：3
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第2期91-105,共15页Xiangyu HONG Junjie MA Shanshan ZHENG Guangyu ZHAO Caiyun FU 
This work was supported by the Zhejiang Provincial Natural Science Foundation of China(No.LD22H310004);the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2022C03005),China.
Recently,the substance P(SP)/neurokinin-1 receptor(NK-1R)system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019(COVID-19).Besides,studies ...
关键词：Neurokinin-1 receptor(NK-1R)antagonist Pathophysiological disorder Tumor target BIOAVAILABILITY NANOENCAPSULATION Synergistic therapy 
Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance被引量：1
《Acta Pharmacologica Sinica》2023年第7期1500-1518,共19页Xin Chai Xue-ping Hu Xin-yue Wang Hua-ting Wang Jin-ping Pang Wen-fang Zhou Jia-ning Liao Lu-hu Shan Xiao-hong Xu Lei Xu Hong-guang Xia Ting-jun Hou Dan Li 
National Key R&D Program of China(2019YFE0111300);National Natural Science Foundation of China(22220102001,22273049);Zhejiang Provincial Natural Science Foundation of China(LD22H300001).
As a major class of medicine for treating the lethal type of castration-resistant prostate cancer(PCa),long-term use of androgen receptor(AR)antagonists commonly leads to antiandrogen resistance.When AR signaling path...
关键词：prostate cancer androgen receptor glucocorticoid receptor dual antagonists antiandrogen resistance 
Targeting the“undruggable”cancer driver genes:Ras,myc,and tp53
《BIOCELL》2023年第7期1459-1472,共14页XINGBO WU DAN PAN SHOUYI TANG YINGQIANG SHEN 
supported by Grants from the National Natural Science Foundation of China(81902784);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-004);the Fund of Sichuan Provincial Department of Science and Technology(2022YFSY0058);the Research Funding(RCDWJS 2020-20);the Research and Development Program(RD-02-202002)from West China School/Hospital of Stomatology Sichuan University.
The term“undruggable”is to describe molecules that are not targetable or at least hard to target pharmacologically.Unfortunately,some targets with potent oncogenic activity fall into this category,and currently litt...
关键词：RAS MYC TP53 Antineoplastic agents PHARMACOLOGY Oncogene proteins Antagonists and inhibitors 
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors被引量：2
《Translational Neurodegeneration》2023年第1期189-204,共16页Yi Xu Yanling Yang Xi Chen Danling Jiang Fei Zhang Yao Guo Bin Hu Guohai Xu Shengliang Peng Lidong Wu Jialing Hu 
supported by grants from the doctoral start-up fund of the Second Affiliated Hospital of Nanchang University(B3150);Jiangxi Provincial Natural Science Foundation(20232BAB216042).
Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society.Neuroinflammation is one of the main factors leading to cognitive impairment.The infl...
关键词：Cognitive impairment NLRP3 inflammasome NEUROINFLAMMATION ANTAGONISTS Pharmacological properties 
Validation of different personalized risk models of chemotherapy-induced nausea and vomiting:results of a randomized,double-blind,phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin被引量：4
《Cancer Communications》2023年第2期246-256,共11页Yuanyuan Zhao Bing Zhao Gang Chen Yinlan Chen Zijun Liao Haiming Zhang Weineng Feng Yinyin Li Heng Weng Weidong Li Yuefen Zhou Biyong Ren Yanda Lu Jianhua Chen Zhenteng Liu Zhenzhong Su Wenliang Wang Li Zhang 
Background:Highly emetogenic chemotherapy induces emesis in cancer patients without prophylaxis.The purpose of this study was to evaluate the efficacy and safety of a fosaprepitant-based triple antiemetic regimen for ...
关键词：APREPITANT chemotherapy-induced nausea and vomiting clinical trial fosaprepitant neurokinin-1 receptor antagonists NOMOGRAM NOMOGRAM personalized risk model 
Effects of the availability of floral resources and neighboring plants on nectar robbery in a specialized pollination system
《Current Zoology》2022年第5期541-548,共8页Júlia Mendonça Almeida Caio César Corrêa Missagia Maria Alice Santos Alves 
the Brazilian National Council for Scientific and Technological Development(CNPq)with a research grant to Maria Alice S.Alves(PQ processes#306.579/2018-9);Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro(FAPERJ)supported Maria Alice S.Alves with research grant(CNE process#E-26/202.835/2018).
Many plants pollinated by nectar-foraging animals have to maintain a balance between legitimate visitor attraction strategies and mechanisms that minimize illegitimate visits.This study investigated how floral display...
关键词：Brazilian Atlantic forest DENSITY floral antagonists Heliconiaceae 
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