BACKGROUND The combination of anti-epidermal growth factor receptor(EGFR)therapy and chemotherapy is currently a preferred first-line treatment for patients with unre-sectable,RAS and BRAF wild-type,left-sided metasta...
supported by the National Natural Science Foundation of China(82203447);the Natural Science Foundation of Sichuan,China(2022NSFSC1424);the Postdoctoral Research Project,West China Hospital,Sichuan University(18HXBH068)。
In cancer,the proto-oncogene RAS frequently mutates at codons 12,13,and 61,with these mutations propelling tumor progression by locking RAS proteins in their active,GTP-bound state(Pylayeva-Gupta et al.,2011;Yang et a...
supported by the 1.3.5 Project for Disciplines of Excellence(No.ZYGD18007);West China Hospital,Sichuan University,the Natural Science Foundation Project of Sichuan Province(No.2022NSFSC1309,China);the National Natural Science Foundation of China(No.82203016).
Extensive evidence has demonstrated that glucagon-like peptide-1 receptor agonists(GLP-1RAs)can ameliorate obesity.Our previous studies revealed that(Ex-4)2-Fc,a long-acting GLP-1RA we developed,depends on the leptin ...