NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors  

作　　者：Yi Xu Yanling Yang Xi Chen Danling Jiang Fei Zhang Yao Guo Bin Hu Guohai Xu Shengliang Peng Lidong Wu Jialing Hu 

机构地区：[1]Department of Emergency Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China [2]Department of Thyroid and Hernia Surgery,The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China [3]Department of Anesthesiology,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China [4]Department of Ultrasound Medicine,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China [5]The Second Affiliated Hospital of Nanchang University,Department of the Second Clinical Medical College of Nanchang University,Nanchang 330006,China

出　　处：《Translational Neurodegeneration》2023年第1期189-204,共16页转化神经变性病（英文）

基　　金：supported by grants from the doctoral start-up fund of the Second Affiliated Hospital of Nanchang University(B3150);Jiangxi Provincial Natural Science Foundation(20232BAB216042).

摘　　要：Cognitive impairment is a multifactorial and multi-step pathological process that places a heavy burden on patients and the society.Neuroinflammation is one of the main factors leading to cognitive impairment.The inflammasomes are multi-protein complexes that respond to various microorganisms and endogenous danger signals,helping to initiate innate protective responses in inflammatory diseases.NLRP3 inflammasomes produce proinflammatory cytokines(interleukin IL-1βand IL-18)by activating caspase-1.In this review,we comprehensively describe the structure and functions of the NLRP3 inflammasome.We also explore the intrinsic relationship between the NLRP3 inflammasome and cognitive impairment,which involves immune cell activation,cell apoptosis,oxidative stress,mitochondrial autophagy,and neuroinflammation.Finally,we describe NLRP3 inflammasome antagonists as targeted therapies to improve cognitive impairment.

关 键 词：Cognitive impairment NLRP3 inflammasome NEUROINFLAMMATION ANTAGONISTS Pharmacological properties 

分 类 号：R741[医药卫生—神经病学与精神病学]