胃癌及肠上皮化生组织中P53、C-myc蛋白表达  

The expression of P53 and C-myc protein in gastric cancer and intestinal metaplasia

作　　者：周洁[1] 李华仁 董红林[1] 张锦波 权莉 

机构地区：[1]第一军医大学分校病理学教研室,广东省广州市510315 [2]广东省一七七医院,广东省广州市510317

出　　处：《第一军医大学分校学报》2004年第1期5-6,22,共3页Journal of Branch Campus of the First Military Medical University

摘　　要：目的 :探讨P5 3、C -myc表达在胃癌发生、发展中的作用。方法 :对 6 0例胃癌、1 0例肠上皮化生组织和 1 0例对照组 ,应用免疫组化检测P5 3和C -myc基因蛋白。结果 :胃癌组的突变P5 3和C -myc基因表达均显著增高 (P >0 .0 1 ) ,而肠上皮化生组中P5 3和C -myc的表达与正常组无显著差异 (P >0 .0 5 ) ,肠上皮化生组的C -myc表达明显低于胃癌组 (P >0 .0 1 )。结论 :P5 3基因发生突变、失活以及C -myc基因激活 ,在胃癌的发生中可能起重要作用 ,检测CPurpose To study the roles of P53 and C-myc protein expression in the carcinogenesis of gastric cancer. Methods P53 and C-myc gene proteins were immunohistochemically examined in 60 patients with gastric carcinoma, 10 patients with intestinal metaplasia and 10 controls. Results In the cancer group the expression of mutant P53 and C-myc was markedly increased ( P >0.01). The expression of mutant P53 and C-myc in intestinal metaplasia group was not significantly higher than those of normal controls ( P <0.05), while the expression of c-myc in the intsetinal metaplasia was signifiantly lower than that in the cancer group ( P >0.01). Conclusion The mutation and inactivation of P53 gene and activation of C-myc gene may play an important role in the gastric cancer. C-myc may be a useful marker in predicting the change from intestinal metaplasia to gastric cancer.

关 键 词：胃癌 P53蛋白 C—myc蛋白 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]