中国神方丙治疗β-地中海贫血症的临床与机理研究  

Clinical and Laboratory Studies on Treatment of β-thalassemia with Chinese Mysterious Medicine (C)

作　　者：吴志奎[1] 陈双厚[1] 姜葆华[1] 李承军[1] 刘云 黄霞珍[1] 陈朝[1] 邱长春[2] 王荣新[3] 查月玉 黄有文[3] 

机构地区：[1]中国中医研究院广安门医院基础研究室 [2]中国医学科学院基础医学研究所 [3]中国人民解放军303医院

出　　处：《中药药理与临床》1991年第5期37-40,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家科委七五攻关项目

摘　　要：β-地中海贫血(以下简称β-地贫)是世界性顽症之一,它是一种遗传性贫血,其分子基础是由于β-基因缺失或功能缺乏,使β-珠蛋白链不能合成导致早期造血障碍。其治疗以输血为主,有的用5氮胞苷(Azac),阿糖胞苷(Arac)羟基脲(HU)等化疗药物治疗。刘氏曾报告马利兰虽能明显提高贫血恒河猴的r-基因表达,使HbF(抗碱血红蛋白)合成,临床上也有一定的效果,但上述这些药物均有很强的副反应。我们根据中医肾藏精生髓”的理论,采用滋补肾阴生血法。The effect of Chinse Mysterious Medicine (C) on β-thalassemia was observed. The β-thalassemia is a hereditary disease caused by the deficiency of β-genes. It is one of the diseases that no cure has been found in the world. Manning No.303 Hospital of Guan-gxi, a high incidence area, took in six children suffering from the disease All cases were proved by the gene analysis. The Chinese Mysterious Medicine (C) wera used to treament the patients for two months. After the treatment, all the patients had showed marked increases in RBC, RetC,Hb,HbF and reticulocytes. It proved that magic capsule has a marked effect in stimulating. And the curative mechanism was discussed.

关 键 词：THALASSEMIA HEMOGLOBIN GLOBIN CHAIN Traditinal CHINESE MEDICA 

分 类 号：R28[医药卫生—中药学]