GLOBIN

作品数：52被引量：67H指数：4
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相关领域：医药卫生更多>>
相关作者：李承军黄有文王荣新邱长春陈朝更多>>
相关机构：南京大学教育部华侨大学北京协和医学院更多>>
相关期刊：《Acta Oceanologica Sinica》《生物技术》《Chinese Journal of Biomedical Engineering(English Edition)》《Open Journal of Genetics》更多>>
相关基金：国家自然科学基金更多>>
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Activation ofγ-globin expression by a common variant disrupting IKAROS-binding motif inβ-thalassemia
《Journal of Genetics and Genomics》2025年第2期157-167,共11页Hualei Luo Jueheng Wang Lang Qin Xinhua Zhang Hailiang Liu Chao Niu Mengyang Song Congwen Shao Peng Xu Miao Yu Haokun Zhang Yuhua Ye Xiangmin Xu 
supported by the National Natural Science Foundation of China(U20A20353 to X.Xu and 81900185 to Y.Ye).
Programmed silencing ofγ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes,which determine the stage-specific genome architecture in this region.Identification of cis-or trans...
关键词：Β-THALASSEMIA Fetal hemoglobin Single nucleotidepolymorphism IKAROS Locus control region 
乌鳢globin基因家族的鉴定及在鳃和鳃上器官中的表达模式分析
《中国海洋大学学报（自然科学版）》2023年第3期141-151,共11页陶泽鑫 李建龙 温海深 李超 孙冬磊 陈基伟 李昀 
山东省鱼类产业技术体系项目(SDAIT-12-03);国家自然科学基金项目(32072947)资助。
为了探究珠蛋白(Globin)在具有耐低氧和空气呼吸能力的乌鳢(Channa argus)中发挥的作用,本文对乌鳢的globin基因家族进行研究。在基因组中鉴定得到18个globin基因,分属于Hb、Mb、Ngb和Cygb四个亚家族,其中Hb亚家族拷贝数最多,达14个,其...
关键词：乌鳢 空气呼吸 globin基因 空气暴露 
Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China被引量：5
《Biomedical and Environmental Sciences》2023年第2期127-134,共8页XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua 
supported by the National Key Research and Development Program of China[2021YFC1005300];the science and technology innovation Program of Hunan Province—Major Scientific and Technological Projects for Collaborative Prevention and Control of Birth Defects in Hunan Province[2019SK1010 and 2019SK1011];Hunan Province Clinical Medical Technology Innovation Guidance Project"Screening,prevention and control of single gene disease carriers and panel research in childbearing age people in Hunan Province"[2021SK50602].
Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening fr...
关键词：THALASSEMIA Carrier rate Molecular spectrum Abnormal hemoglobin variants α-globin triplication 
Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies被引量：18
《Cell Research》2020年第3期276-278,共3页Liren Wang Linxi Li Yanlin Ma Handan Hu Qi Li Yang Yang Wenbang Liu Shuming Yin Wei Li Bin Fu Ryo Kurita Yukio Nakamura Mingyao Liu Yongrong Lai Dali Li 
partially supported by grants from the National Key R&D Program of China(2019YFA0110802,2019YFA0802800);Major Science and Technology Program of Hainan Province(ZDKJ2017007);the National Natural Science Foundation of China(81670470,81873685);grants from the Shanghai Municipal Commission for Science and Technology(18411953500);the Innovation program of Shanghai Municipal Education Commission(2019-01-07-00-05-E00054);the Fundamental Research Funds for the Central Universities.
Dear Editor,Mutations in the β-globin gene,the essential component of adult hemoglobin(HbA;a2p2),results in either a production of aberrant sickle hemoglobin(HbS)leading to sickle cell disease(SCD)or an insufficient ...
关键词：IMPAIRED FETAL ANEMIA 
Reduction of BCL11A in hematopoietic stem cells through gene editing:new strategy to ameliorate the severe b-globin disorders sickle cell disease
《Science Bulletin》2019年第21期1562-1564,共3页Weiqi Hong Mengyuan Huang Yuquan Wei Xiawei Wei 
Site-specific gene editing is of great importance in precise medicine. Two conventional genome editing methods, Zine finger nucleases (ZFNs) and transcription activator-like effector nucleases(TALENs), are based on pr...
关键词：CRISPR/Cas9 TALENs ZFNs 
Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage被引量：2
《Acta Pharmaceutica Sinica B》2019年第6期1253-1258,共6页Xiwei Chen Lu Wang Jinmei Zhang Tao Jiang Changhua Hu Dehai Li Yi Zou 
supported by the National Natural Science Foundation of China(31870022);the Fundamental Research Funds for the Central Universities(XDJK2018B035 and 201941001,China);the Scientific Research Starting Foundation of Southwest University(SWU117034,China);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao,China)(No.2018SDKJ0401-2);Taishan Scholar Youth Expert Program in Shandong Province(tsqn201812021,China);supported by the Venture&Innovation Support Program for Chongqing Overseas Returnees and the Thousand Young Talents Program of China.
Mycophenolic acid(MPA,1)and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases.Despite chemical synthetic achievements,the biosynthetic formation of a ...
关键词：BIOSYNTHESIS Mycophenolic acid PRENYLATION C-C bond CLEAVAGE GLOBIN ENZYME 
Long non-coding RNAs during normal erythropoiesis被引量：1
《Blood Science》2019年第2期137-140,共4页Changlu Xu Lihong Shi 
supported by the National Key Research and Development Program of China(2016YFA0102300 and 2017YFA0103102);CAMS Innovation Fund for Medical Sciences(2016-I2M-3-002,2016-I2M-1-018 and 2017-I2M-1-015);National Natural Science Foundation of China(81870089 and 81700105);CAMS Medical Epigenetics Research Center(2018PT31033);Supported by the Fundamental Research Funds for the Central Universities(3332018157);State Key Laboratory of Experimental Hematology Research Grant(157-z18-07).
The transcription of essentially the entire eukaryotic genome produces a huge amount of non-coding RNAs.Among them,long noncoding RNAs(lncRNAs)consist of a significant portion that widely exists across mammal genome,g...
关键词：ERYTHROPOIESIS Globin regulation Heme biosynthesis Long non-coding RNAs 
Widely distribution of hematological parameters in thalassemia patients with similar α-globin genotype
《Frontiers in Biology》2018年第6期469-474,共6页Bijan Keikhaei Pejman Salehi-Fard Mostafa Paridar Mehraneh Karimzadeh Razie Dehghani Asma Zamiri Vahideh Takhviji 
Ginseng-Derived Panaxadiol Saponins Promote Hematopoiesis Recovery in Cyclophosphamide-Induced Myelosuppressive Mice:Potential Novel Treatment of Chemotherapy-Induced Cytopenias被引量：11
《Chinese Journal of Integrative Medicine》2018年第3期200-206,共7页SUN Xin ZHAO Yan-na QIAN Song GAO Rui-lan YIN Li-ming WANG Li-pei CHONG Beng-hock ZHANG Su-zhan 
Supported by the Science and Technology Program Project of Zhejiang Province(No.2015C33173);Chinese Medicine Foundation of Young Talents in Zhejiang Province(No.2014ZQ006);Australia-China Institutional Links Research Program sponsored by the International Development Program of Education Australia(No.IDP 2-8)
Objective：To investigate the potential efficacy of panaxadiol saponins component（PDS-C）,a biologically active fraction isolated from total ginsenosides,to reverse chemotherapy-induced myelosuppression and pancytope...
关键词：panaxadiol saponins component ginsenosides chemotherapy-induced myelosuppression mitogen-activated protein kinase extracellular signal-regulated kinase receptor tyrosine kinase globin transcription factor 1 Chinese medicine 
PKR activation and eIF2α phosphorylation mediate human globin mRNA splicing at spliceosome assembly被引量：1
《Cell Research》2017年第5期688-704,共17页Lena Ilan Farhat Osman Lise Sarah Namer Einav Eliahu Smadar Cohen-Chalamish Yitzhak Ben-Asouli Yona Banai Raymond Kaempfer 
Short elements in mammalian mRNA can control gene expression by activating the RNA-dependent protein kinase PKR that attenuates translation by phosphorylating cytoplasmic eukaryotic initiation factor 2a （eIF2α）. We...
关键词：globin mRNA splicing eIF2α phosphorylation PKR RNA activator of PKR spliceosome assembly 
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