Long non-coding RNAs during normal erythropoiesis  

作　　者：Changlu Xu Lihong Shi 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Hematological Disorders,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,China [2]Center for Stem Cell Medicine,Chinese Academy of Medical Sciences&Department of Stem Cells and Regenerative Medicine,Peking Union Medical College,Tianjin,China

出　　处：《Blood Science》2019年第2期137-140,共4页血液科学（英文）

基　　金：supported by the National Key Research and Development Program of China(2016YFA0102300 and 2017YFA0103102);CAMS Innovation Fund for Medical Sciences(2016-I2M-3-002,2016-I2M-1-018 and 2017-I2M-1-015);National Natural Science Foundation of China(81870089 and 81700105);CAMS Medical Epigenetics Research Center(2018PT31033);Supported by the Fundamental Research Funds for the Central Universities(3332018157);State Key Laboratory of Experimental Hematology Research Grant(157-z18-07).

摘　　要：The transcription of essentially the entire eukaryotic genome produces a huge amount of non-coding RNAs.Among them,long noncoding RNAs(lncRNAs)consist of a significant portion that widely exists across mammal genome,generating from high-throughput transcriptomic studies in the last decade.Although the functions of most lncRNAs remain to be further investigated,many of them have already been shown to play critical roles during normal development and disease conditions.Increasing evidence indicates that lncRNAs involve in versatile biological processes during erythroid proliferation and differentiation,including erythroid cell survival,heme metabolism,globin switching and regulation,erythroid enucleation,etc,via cis-or trans-mediated molecular mechanisms.In this review,we focus on recent advances regarding the functions and mechanisms of lncRNAs in normal erythropoiesis.

关 键 词：ERYTHROPOIESIS Globin regulation Heme biosynthesis Long non-coding RNAs 

分 类 号：R73[医药卫生—肿瘤]