ERYTHROPOIESIS

作品数：39被引量：42H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：齐亚德苏冬梅沈倍奋刘桂生陈清轩更多>>
相关机构：华中科技大学沈阳三生制药股份有限公司山东第一医科大学(山东省医学科学院)华西医科大学更多>>
相关期刊：《Open Journal of Nephrology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Frontiers in Biology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution
《Zoological Research》2025年第1期165-176,共12页Eun Jung Kwon Hyeon Mi Sung Hansong Lee Soyul Ahn Yejin Kim Chae Rin Lee Kihun Kim Kyungjae Myung Won Kyu Kim Dokyoung Kim Sanghwa Jeong Chang-Kyu Oh Yun Hak Kim 
supported by the Institute for Basic Science (IBS-R022-D1);Global Learning&Academic Research Institution for Master’s/Ph D students and Post-Doc Program of the National Research Foundation of Korea Grant funded by the Ministry of Education (RS-2023-00301938);National Research Foundation of Korea Grant funded by the Korean government (RS-2024-00406152,MSIT);Additional financial support was provided by the 2024 Post-Doc Development Program of Pusan National University,Korea Medical Institute,and KREONET。
Polystyrene nanoparticles pose significant toxicological risks to aquatic ecosystems,yet their impact on zebrafish(Danio rerio)embryonic development,particularly erythropoiesis,remains underexplored.This study used si...
关键词：Polystyrene nanoparticles Zebrafish embryos Single-cell RNA sequencing ERYTHROPOIESIS 
BRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK signaling
《Signal Transduction and Targeted Therapy》2025年第1期256-270,共15页Shunkang Wu Yuelin Deng Haobo Sun Xuewen Liu Shuo Zhou Hanxi Zhao Huan Li Fusheng Guo Qiuyu Yue Fan Wu Xinying Zhao Na Li Shicong Zhu Qi Hu Si Xie Jie Zheng Meng Lv Yuan Kong Xiao-Jun Huang Xiaoguang Lei Xiangmin Tong Xiaofei Gao Hsiang-Ying Lee 
support from the National Key R&D Program of China(2022YFA1103300);SLS-Qidong Innovation Fund(8410101639);the Peking-Tsinghua Center for Life Sciences and School of Life Sciences,Peking University to H.-Y.L.;grant support from the Zhejiang Provincial Natural Science Foundation of China(LR20C070001);“Leading Goose”R&D Program(2024C03089);the Science and Technology Department of Zhejiang Province(Key Project,2021C03011)”to X.G.
Erythropoiesis is a crucial process in hematopoiesis,yet it remains highly susceptible to disruption by various diseases,which significantly contribute to the global challenges of anemia and blood shortages.Current tr...
关键词：ANEMIA BRAF ACTIVATION 
The non-canonical poly(A)polymerase FAM46C promotes erythropoiesis
《Journal of Genetics and Genomics》2024年第6期594-607,共14页Ke Yang Tiangi Zhu Jiaying Yin Qiaoli Zhangg Jing Li Hong Fan Gajing Han Weiyin Xu Nan Liu Xiang Lv 
funded by the Starting Fund from Zhejiang University to N.L.and grants to X.L.from National Natural Science Foundation of China(82170120 and 81670108);CAMS Initiative for Innovative Medicine(2017-12M-B&R-04);Medical Epigenetics Research Cen-ter,CAMS(2018PT31015);the State Key Laboratory of Medical Molecular Biology(2060204);Haihe L aboratory of Cell Ecosystem Innovation Fund(22HHXBSS00008).
The post-transcriptional regulation of mRNA is a crucial component of gene expression.The disruption of this process has detrimental effects on the normal development and gives rise to various diseases.Searching for n...
关键词：FAM46C TENT5C Poly(A)polymerase ERYTHROBLASTS Post-transcriptional regulation Erythroid-specific enhancer 
Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis
《Genomics, Proteomics & Bioinformatics》2023年第6期1117-1132,共16页Yongshuai Han Shihui Wang Yaomei Wang Yumin Huang Chengjie Gao Xinhua Guo Lixiang Chen Huizhi Zhao Xiuli An 
supported by the Science and Technology Research Project of Henan(Grant No.232102311003);the National Natural Science Foundation of China(Grant No.U1804282)。
The fetal liver(FL)is the key erythropoietic organ during fetal development,but knowledge on human FL erythropoiesis is very limited.In this study,we sorted primary erythroblasts from FL cells and performed RNA sequen...
关键词：Human fetal liver Terminal erythropoiesis TRANSCRIPTOME Immortalized erythroid cell line ENUCLEATION 
Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance被引量：1
《Cell Regeneration》2023年第1期295-312,共18页WenYe Liu ShuHui Lin LingYa Li ZhiPeng Tai Jing-Xia Liu 
supported by the Nation Natural Science Foundation of China(Program No.32070807);by the National Key R&D Program of China(2018YFD0900101);by the project 2020SKLBC-KF06 of State Key Laboratory of Biocontrol.
EAF1 and EAF2,the eleven-nineteen lysine-rich leukemia(ELL)-associated factors which can assemble to the super elongation complex(AFF1/4,AF9/ENL,ELL,and P-TEFb),are reported to participate in RNA polymeraseⅡto active...
关键词：EAF1/2 gata1a/scl/lmo2 ERYTHROPOIESIS H3K27me3 WNT/β-Catenin signaling TCF4 
Post-transcriptional regulation of erythropoiesis被引量：1
《Blood Science》2023年第3期150-159,共10页Yanan Li Haihang Zhang Bin Hu Pan Wang Wei Wang Jing Liu 
supported by grants from the National Natural Science Foundation of China(Grant numbers 81920108004 and 82270127);the Fundamental Research Funds of the Central Universities of Central South University(Grant number 2021zzts0562);the Fundamental Research Funds for the Scientific Research Innovation Project of Hunan Province(Grant number CX20210182).
Erythropoiesis is a complex,precise,and lifelong process that is essential for maintaining normal body functions.Its strict regulation is necessary to prevent a variety of blood diseases.Normal erythropoiesis is preci...
关键词：ERYTHROPOIESIS mRNA stability Noncoding RNA Post-transcriptional regulation 
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors被引量：2
《Cancer Communications》2023年第6期637-660,共24页Kayoko Hosaka Chenchen Wang Shiyue Zhang Xue Lv Takahiro Seki Yin Zhang Xu Jing Jieyu Wu Qiqiao Du Xingkang He Yulong Fan Xuan Li Makoto Kondo Masahito Yoshihara Hong Qian Lihong Shi Ping Zhu Yuanfu Xu Yunlong Yang Tao Cheng Yihai Cao 
CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-017;National Natural Science Foundation of China,Grant/Award Number:81970107;State Key Laboratory of Experimental Hematology Research,Grant/Award Number:Z22-02;Tianjin“131”Science Fund for Creative Research Groups,Grant/Award Number:2021;Swedish Research Council,Grant/Award Numbers:2016-02215,2019-01502,2020-06121,2021-06122;National Key R&D Program of China,Grant/Award Number:2020YFC0846600;Hong Kong Centre for Cerebro-cardiovascular Health Engineering;Swedish Cancer Foundation,Grant/Award Number:200734PjF;Swedish Children’s Cancer Foundation,Grant/Award Number:PR2018-0107;Strategic Research Areas(SFO)-Stem Cell and Regenerative Medicine Foundation;Karolinska Institute distinguished professor award;Karolinska Institute Foundation;Scandinavia-Japan Sasakawa Foundation,Grant/Award Number:81801163;Doctor Fund of Shandong Natural Science Foundation,Grant/Award Number:ZR201807060846;Japan Society for the Promotion of Science(JSPS)Overseas Research Fellowships。
Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesi...
关键词：cancer HEMATOPOIESIS PDGF-B perivascular localized cell stem cell tumor vasculature 
Characteristics of bone marrow compensatory erythropoiesis in hereditary spherocytosis
《China Medical Abstracts(Internal Medicine)》2022年第2期122-123,共2页LI Xiaoxia 
Objective To reveal the compensatory features of bone marrow (BM) erythropoiesis in hereditary spherocytosis (HS) and to explore the effect of diferent hemoglobin levels on this compensation.Methods Clinical and labor...
关键词：MARROW HEREDITARY BONE 
Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis被引量：2
《Genomics, Proteomics & Bioinformatics》2021年第3期358-376,共19页Zijuan Xin Wei Zhang Shangjin Gong Junwei Zhu Yanming Li Zhaojun Zhang Xiangdong Fang 
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA 16010602);the National Key R&D Program of China(Grant Nos.2016YFC0901700,2017YFC0907400,and 2018YFC0910700);the National Natural Science Foundation of China(Grant Nos.81670109,81870097,81700097,81700116,and 82070114).
There is an imbalance between the supply and demand of functional red blood cells(RBCs)in clinical applications.This imbalance can be addressed by regenerating RBCs using several in vitro methods.Induced pluripotent s...
关键词：scRNA-seq IPSC HEMATOPOIESIS ERYTHROPOIESIS Differentiation trajectory 
ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1被引量：1
《Acta Pharmacologica Sinica》2021年第3期414-421,共8页Fang-fang Li Yu-lai Liang Xiao-shuai Han Ya-na Guan Jian Chen Ping Wu Xian-xian Zhao Qing Jing 
supported in part by the National Key Research and Development Program of China(2019YFA0802700,2017YFA0103700);the National Natural Science Foundation of China(91739301,91339205,81130005).
In the past two decades,purinergic signaling has emerged as a key regulator of hematopoiesis in physiological and pathological conditions.ADP receptor P2y12 is a crucial component of this signaling,but whether it is i...
关键词：purinergic signaling P2y12 primitive hematopoiesis ERYTHROPOIESIS Gatal ZEBRAFISH 
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