CAMS Innovation Fund for Medical Sciences(2021‐I2M‐1‐017),the National Natural Science Foundation of China(81970107),State Key Laboratory of Experimental Hematology Research Grant(Z22‐02)和Tianjin“131”Science Fund for Creative Research Groups(2021)基金支持;Yihai Cao获得the Swed is h Research Counc i l(2016‐02215,2019‐01502,2020‐06121,2021‐06122),National Key R&D Program of China(2020YFC0846600);the Hong Kong Centre for Cerebro‐cardiovascular Health Engineering,the Swedish Cancer Foundation(200734PjF),the Swedish Children's Cancer Foundation(PR2018‐0107);the Strategic Research Areas(SFO)‐Stem Cell and Regenerative Medicine Foundation,the Karolinska Institute Foundation(2020‐02080);the Karolinska Institute distinguished professor award,and the Karolinska Institute Foundation(2020‐02588)基金支持;Kayoko Hosaka获得the Karolinska Institute Foundation基金支持;Takahiro Seki获得the Scandinavia‐Japan Sasakawa Foundation基金支持;Xu Jing获得the National Natural Science Foundation of China(81801163)and Doctor Fund of Shandong Natural Science Foundation(ZR201807060846)基金支持;Masahito Yoshihara获得the Japan Society for the Promotion of Science(JSPS)Overseas Research Fellowships基金支持。
CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-017;National Natural Science Foundation of China,Grant/Award Number:81970107;State Key Laboratory of Experimental Hematology Research,Grant/Award Number:Z22-02;Tianjin“131”Science Fund for Creative Research Groups,Grant/Award Number:2021;Swedish Research Council,Grant/Award Numbers:2016-02215,2019-01502,2020-06121,2021-06122;National Key R&D Program of China,Grant/Award Number:2020YFC0846600;Hong Kong Centre for Cerebro-cardiovascular Health Engineering;Swedish Cancer Foundation,Grant/Award Number:200734PjF;Swedish Children’s Cancer Foundation,Grant/Award Number:PR2018-0107;Strategic Research Areas(SFO)-Stem Cell and Regenerative Medicine Foundation;Karolinska Institute distinguished professor award;Karolinska Institute Foundation;Scandinavia-Japan Sasakawa Foundation,Grant/Award Number:81801163;Doctor Fund of Shandong Natural Science Foundation,Grant/Award Number:ZR201807060846;Japan Society for the Promotion of Science(JSPS)Overseas Research Fellowships。
Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesi...