This study was supported by the Natural Science Foundation of Guangdong Province,China(2019A1515011614 to ZC);the Science and Technology Program of Guangzhou(202002030483 to ZC);the National Natural Science Foundation of China(81601942 to ZC and 81830079 to BY);the Outstanding Youths Development Scheme of Southern Medical University(2021YQPY008 to ZC);the National Key R&D Program of China(2019YFA0111900 to CL).
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has sho...