PRENYLATION

作品数：8被引量：7H指数：2
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Catalytic C2 prenylation of unprotected indoles:Late‐stage diversification of peptides and two‐step total synthesis of tryprostatin B
《Chinese Journal of Catalysis》2021年第9期1593-1607,共15页Yan‐Cheng Hu Ying Li Ding‐Wei Ji Heng Liu Hao Zheng Gong Zhang Qing‐An Chen 
国家自然科学基金(21801239,22071239).
C2 prenylated indoles are widespread in a variety of bioactive natural alkaloids.Therefore,theselective installation of prenyl group at C2 position of NH indoles is of great significance.However,the known protocols ge...
关键词：Indole prenylation Step economy Atom economy TRYPTOPHAN Peptide diversification Total synthesis 
Post-translational modification of KRAS: potential targets for cancer therapy被引量：1
《Acta Pharmacologica Sinica》2021年第8期1201-1211,共11页Wei-hua Wang Tao Yuan Mei-jia Qian Fang-jie Yan Liu Yang Qiao-jun He Bo Yang Jin-jian Lu Hong Zhu 
Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis.Among them,KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to interven...
关键词：ONCOGENE KRAS post-translational modification PRENYLATION postprenylation PALMITOYLATION ubiquitination phosphorylation SUMOYLATION acetylation NITROSYLATION cancer therapy 
Microbial soluble aromatic prenyltransferases for engineered biosynthesis
《Synthetic and Systems Biotechnology》2021年第2期51-62,共12页He-Ping Chen Ikuro Abe 
supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology,Japan(JSPS KAKENHI Grant No.JP16H06443 and JP20H00490);Japan Science and Technology Agency(JST SICORP Grant No.JPMJSC1701);H.P.C.is a recipient of the JSPS Postdoctoral Fellowship for Foreign Researchers(ID No.P19413).
Prenyltransferase(PTase)enzymes play crucial roles in natural product biosynthesis by transferring isoprene unit(s)to target substrates,thereby generating prenylated compounds.The prenylation step leads to a diverse g...
关键词：Microbial prenyltransferase BIOSYNTHESIS Enzyme engineering PRENYLATION Synthetic biology 
Acid-catalyzed chemoselective C-and O-prenylation of cyclic 1,3-diketones被引量：1
《Chinese Journal of Catalysis》2020年第9期1401-1409,共9页Ying Li Yan-Cheng Hu Ding-Wei Ji Wei-Song Zhang Gu-Cheng He Yu-Feng Cong Qing-An Chen 
国家自然科学基金(21702204,21801239).
The chemoselective C-and O-prenylation of cyclic 1,3-diketones was achieved by tuning the prenyl source and catalyst.In the presence of the solid acid Nafion,the coupling of 1,3-cyclohexanediones with isoprene gave C-...
关键词：5-Chromenones 1 3-Cyclohexanediones O-Prenylation [3+3]Annulation ISOPRENE Prenol 
Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage被引量：2
《Acta Pharmaceutica Sinica B》2019年第6期1253-1258,共6页Xiwei Chen Lu Wang Jinmei Zhang Tao Jiang Changhua Hu Dehai Li Yi Zou 
supported by the National Natural Science Foundation of China(31870022);the Fundamental Research Funds for the Central Universities(XDJK2018B035 and 201941001,China);the Scientific Research Starting Foundation of Southwest University(SWU117034,China);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao,China)(No.2018SDKJ0401-2);Taishan Scholar Youth Expert Program in Shandong Province(tsqn201812021,China);supported by the Venture&Innovation Support Program for Chongqing Overseas Returnees and the Thousand Young Talents Program of China.
Mycophenolic acid(MPA,1)and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases.Despite chemical synthetic achievements,the biosynthetic formation of a ...
关键词：BIOSYNTHESIS Mycophenolic acid PRENYLATION C-C bond CLEAVAGE GLOBIN ENZYME 
Biocatalytic bis-C-alkylation of phenolics using one-pot cascades with promiscuous C-glycosyltransferase and prenyltransferase
《Journal of Chinese Pharmaceutical Sciences》2018年第4期241-250,共10页Dawei Chen Lili Sun Ridao Chen Kebo Xie Lin Yang Jungui Dai 
National Natural Science Foundation of China(Grant Nos.21572277,81573317 and 81703369);CAMS Innovation Fund for Medical Sciences(CIFMS-2016-I2M-3-012)
C-glycosylation and C-prenylation are two important C-C-bond forming reactions for preparation,diversification and structural modification of natural/unnatural products with pharmacological activities.Here,we describe...
关键词：Bis-C-alkylation Enzymatic glycosylation Enzymatic prenylation Enzyme cascades 
Synthesis of Bioactive Natural Polymethoxyflavones and Their Vinyl Ether Derivatives被引量：1
《Chemical Research in Chinese Universities》2012年第4期631-636,共6页CAI Shuang-lian LIU Shuang LIU Li WANG Qiu-an 
Supported by the Science & Technology Planning Project of Hunan Province,China (No.2011FJ3214)
Bioactive natural polymethoxyflavones 1―6 and their vinyl ether derivatives 7―15 were synthesized by bromination,aromatic nucleophilic substitution,methylation,benzyl protection,Friedel-Crafts acetylation,aldol cond...
关键词：Flavonoid Polymethoxyflavone PRENYLATION FARNESYLATION 
Do statins reduce hepatitis C RNA titers during routine clinical use?被引量：2
《World Journal of Gastroenterology》2009年第40期5020-5027,共8页Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan 
Supported by The Veterans Health Administration Research Career Development Award (DEK)
AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were revie...
关键词：Hepatitis C 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor STATINS Geranylgeranyl PRENYLATION 
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