PALMITOYLATION

作品数：31被引量：92H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：林芳王雁秦正红更多>>
相关机构：浙江大学苏州大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Frontiers of Medicine》《Zoological Research》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山西省自然科学基金更多>>
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Palmitoyltransferase ZDHHC3 is essential for the oncogenic activity of PML/RARαin acute promyelocytic leukemia
《Acta Pharmacologica Sinica》2025年第2期462-473,共12页Xue-jing Shao Wei Wang Ai-xiao Xu Xiao-tian Qi Min-yi Cai Wen-xin Du Ji Cao Qiao-jun He Mei-dan Ying Bo Yang 
supported by grants from the National Key R&D Program of China(2021YFA1300604);the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province(LR24H310001);the Fundamental Research Funds for the Central Universities.
The oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor alpha(PML/RARα)is critical for acute promyelocytic leukemia(APL).PML/RARαinitiates APL by blocking the differentiation and increasing the se...
关键词：acute promyelocytic leukemia PML/RARa drug resistance PALMITOYLATION ZDHHC3 
Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation
《Zoological Research》2025年第1期3-14,共12页Li Nie Xiang-Yu Wu Zi-Yue Zhao Chen-Jie Fei Ting-Fang Zhu Jian-Zhong Shao Jiong Chen 
supported by the National Natural Science Foundation of China (32473194);Natural Science Foundation of Zhejiang Province (LY23C190002);Natural Science Foundation of Ningbo City (202003N4011);One Health Interdisciplinary Research Project of Ningbo University (HZ202201)。
NLRP3 inflammasome activation is pivotal for cytokine secretion and pyroptosis in response to diverse stimuli,playing a crucial role in innate immunity.While extensively studied in mammals,the regulatory mechanisms go...
关键词：NLRP3 PALMITOYLATION zDHHC18 TELEOST Inflammasome activation 
S-acylation of Ca^(2+)transport proteins in cancer
《Chronic Diseases and Translational Medicine》2024年第4期263-280,共18页Sana Kouba Nicolas Demaurex 
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung(Grant/Award Number:310030_189042)。
Alterations in cellular calcium(Ca^(2+))signals have been causally associated with the development and progression of human cancers.Cellular Ca^(2+)signals are generated by channels,pumps,and exchangers that move Ca^(...
关键词：Ca^(2+)signaling Ca^(2+)transport proteins CANCER S-ACYLATION S-palmitoylation 
Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system
《Signal Transduction and Targeted Therapy》2024年第10期4683-4699,共17页Yanli Chang Jiangli Zhu Xiaopeng Li Yi Deng Birou Lai Yidan Ma Jia Tong Huicong Liu Juanjuan Li Chenyu Yang Qiao Chen Chengbiao Lu Yinming Liang Shiqian Qi Xiaoning Wang Eryan Kong 
National Natural Science Foundation of China(Grant No.32100776 to Y.L.C.,and No.32371309 to E.Y.K.);The genetic modification of cell lines and mouse were supported by 111 program(D20036).
The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoy...
关键词：MYELIN SYSTEM TOGETHER 
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
《Cell Research》2024年第10期675-676,共2页Ella Hartenian Petr Broz 
Gasdermin D(GSDMD)is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation.In a recent study in Nature,Du et al.report that S-palmitoylation of human GSDMD at Cys191(mouse Cys19...
关键词：GSDMD stability. 
Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases
《Cellular & Molecular Immunology》2024年第7期787-789,共3页Binhui Zhou Mengjie Zhang Haoyuan Ma Ying Wang Juanjuan Qiu Yang Liu Liaoxun Lu Tianhan Li Lichen Zhang Rong Huang Yanrong Gu Eryan Kong Yinming Liang 
supported by the National Natural Science Foundation of China(Grant no.32000491 to BHZ);projects 222300420015 and 2023DK2005 to YML;a start-up fund from Xinxiang Medical University(505483,to BHZ).
Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and...
关键词：FOXP3 HOMEOSTASIS function 
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
《Acta Pharmacologica Sinica》2024年第6期1214-1223,共10页Bin Lu Yi-yun Sun Bo-ya Chen Bo Yang Qiao-jun He Jun Li Ji Cao 
supported by grants from Zhejiang Provincial Natural Science Foundation of China(LR22H310002 to JC);the National Natural Science Foundation of China(No.82330114 to QH);the Fundamental Research Funds for the Central Universities(226-2023-00059).
CD80 is a transmembrane glycoprotein belonging to the B7 family,which has emerged as a crucial molecule in T cell modulation via the CD28 or CTLA4 axes.CD80-involved regulation of immune balance is a finely tuned proc...
关键词：CD80 zDHHC20 S-palmitoylation costimulatory signals T cell activation 
ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification被引量：1
《Frontiers of Medicine》2023年第4期685-698,共14页Wenle Ye Jinghan Wang Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang Jiajia Pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin 
supported by the key international cooperation projects of the National Natural Science Foundation of China(No.81820108004);the major projects of the Zhejiang Provincial Department of Science and Technology(No.2021C03123);the Pediatric Leukemia Diagnosis and Therapeutic Technology Research Center of Zhejiang Province(No.JBZX-201904).
Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5...
关键词：acute myeloid leukemia acyl-CoA synthetase long chain family member 5 WNT3A PALMITOYLATION ABT-199 
Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma
《Frontiers of Medicine》2022年第5期784-798,共15页Yan Zhang Baoyuan Zhang Yongyun Li Yuting Dai Jiaoyang Li Donghe Li Zhizhou Xia Jianming Zhang Ping Liu Ming Chen Bo Jiao Ruibao Ren 
This work was supported by the Key Project of National Natural Science Foundation of China(No.81530006 to Ruibao Ren);Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to Ruibao Ren);National Natural ScienceFoundation of China(No.81870112 to Ruibao Ren,No.81770171 to Bo Jiao,and No.81970134 to Ping Liu);Samuel Waxman Cancer Research Foundation(to Ruibao Ren);the Innovative Research Team of High-level Local Universities in Shanghai.
More than 85%of patients with uveal melanoma(UM)carry a GNAQ or GNA11 mutation at a hotspot codon(Q209)that encodes G proteinαsubunit q/11 polypeptides(Gα_(q/11)).GNAQ/11 relies on palmitoylation for membrane associ...
关键词：uveal melanoma mutant GNAQ/11 PALMITOYLATION BCL2 combination target therapy 
Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth被引量：8
《Science China(Life Sciences)》2022年第10期2017-2030,共14页Xuan Pei Kai-Yue Li Yuan Shen Jin-Tao Li Ming-Zhu Lei Cai-Yun Fang Hao-Jie Lu Hui-Juan Yang Wenyu Wen Miao Yin Jia Qu Qun-Ying Lei 
supported by the National Key Research and Development Program of China (2020YFA0803402 and2019YFA0801703);the National Natural Science Foundation of China(81872240,81802745,81790250/81790253 and 91959202);Innovation Program of Shanghai Municipal Education Commission (N173606)。
Epithelial ovarian cancer(EOC) exhibits strong dependency on the tricarboxylic acid(TCA) cycle and oxidative phosphorylation to fuel anabolic process.Here,we show that malate dehydrogenase 2(MDH2),a key enzyme of the ...
关键词：EOC MDH2 cysteine palmitoylation ZDHHC18 GLUTAMINE 
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