Distinct palmitoylation of Foxp3 regulates the function of regulatory T cells via palmitoyltransferases  

作　　者：Binhui Zhou Mengjie Zhang Haoyuan Ma Ying Wang Juanjuan Qiu Yang Liu Liaoxun Lu Tianhan Li Lichen Zhang Rong Huang Yanrong Gu Eryan Kong Yinming Liang 

机构地区：[1]Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,453003,China [2]Laboratory of Mouse Genetics,Institute of Psychiatry and Neuroscience,Xinxiang Medical University,Xinxiang,453003,China [3]Laboratory of Genetic Regulators in the Immune System,Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine,Xinxiang Medical University,Xinxiang,453003,China [4]Basic Medical College,Xinxiang Medical University,Xinxiang,453003,China [5]Center of Disease Model and Immunology,Hunan Academy of Chinese Medicine,Changsha,China

出　　处：《Cellular & Molecular Immunology》2024年第7期787-789,共3页中国免疫学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant no.32000491 to BHZ);projects 222300420015 and 2023DK2005 to YML;a start-up fund from Xinxiang Medical University(505483,to BHZ).

摘　　要：Regulatory T cells(Tregs)play pivotal roles in maintaining immune homeostasis and preventing excessive immune responses in vivo.As key players in suppressing immune reactions,they help to preserve immune tolerance and are thus crucial for preventing autoimmune diseases.Within the tumor microenvironment(TME),Tregs facilitate tumor immune evasion by impairing the activity of effector cells via multiple mechanisms,thus contributing to the initiation and progression of tumors[1].To perform this regulatory function,Tregs depend on the master transcription factor forkhead box protein p3(Foxp3)[2].The expression of Foxp3 has emerged as indispensable for the development and optimal function of Tregs[3].Interestingly,different posttranslational modifications,including phosphorylation,ubiquitination,glycosylation,and acetylation,exert significant regulatory effects on the biological function of Foxp3[4-8].

关 键 词：FOXP3 HOMEOSTASIS function 

分 类 号：R392[医药卫生—免疫学]