S-acylation of Ca^(2+)transport proteins in cancer  

作　　者：Sana Kouba Nicolas Demaurex 

机构地区：[1]Department of Cell Physiology and Metabolism,Centre Médical Universitaire,University of Geneva,Geneva,Switzerland

出　　处：《Chronic Diseases and Translational Medicine》2024年第4期263-280,共18页慢性疾病与转化医学（英文版）

基　　金：Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung(Grant/Award Number:310030_189042)。

摘　　要：Alterations in cellular calcium(Ca^(2+))signals have been causally associated with the development and progression of human cancers.Cellular Ca^(2+)signals are generated by channels,pumps,and exchangers that move Ca^(2+)ions across membranes and are decoded by effector proteins in the cytosol or in organelles.S-acylation,the reversible addition of 16-carbon fatty acids to proteins,modulates the activity of Ca^(2+)transporters by altering their affinity for lipids,and enzymes mediating this reversible post-translational modification have also been linked to several types of cancers.Here,we compile studies reporting an association between Ca^(2+)transporters or S-acylation enzymes with specific cancers,as well as studies reporting or predicting the S-acylation of Ca^(2+)transporters.We then discuss the potential role of S-acylation in the oncogenic potential of a subset of Ca^(2+)transport proteins involved in cancer.

关 键 词：Ca^(2+)signaling Ca^(2+)transport proteins CANCER S-ACYLATION S-palmitoylation 

分 类 号：R730.2[医药卫生—肿瘤]