未成熟胎兔肺透明膜病模型的实验观察  

EXPERIMENTAL OBSERVATION ON HYALINE MEMBRANE DISEASE IN PREMATURE RABBITS

作　　者：陈超[1] 金汉珍[1] 杨幼明[2] 邵晓文 赵为之[2] 杨骏华 

机构地区：[1]上海医科大学儿科医院 [2]上海医科大学实验动物部

出　　处：《实验动物与比较医学》1991年第2期68-70,共3页Laboratory Animal and Comparative Medicine

基　　金：国家"七.五"攻关课题;编号:75-66-02-20

摘　　要：本实验观察胎龄27天未成熟兔支气管肺泡灌洗液(BALF)中肺表面活性物质(PS)生化成分和表面活性、肺压力-容量(P-V)滞后环及肺病理变化。并与足月新生兔相比。结果未成熟兔PS的TPL、PC、PG、L/S明显减少,r_(max)、r_(min)明显升高,RI、SI、Harea明显降低;肺P-V滞后环缩小;两肺肺泡广泛萎陷,气道上皮损害及透明膜形成。提示胎龄27天未成熟兔有明显的HMD变化,可作为HMD理想的动物模型。Premature rabbits of gestational age 27 days were used as model of hyaline mem-brane disease (HMD). The biochemical compositions and the surface activities of pul-monary surfactant in bronchoalveolar lavage fluid (BALF), pressure-volume (P-V)loops and pathological changes of the lungs were determined. Comparing with those in mature neonate rabbits, TPL, PC, PG and L/S ratio lowered, surface activities de-creased, lung P-V loop degraded, alveolar collapse, necrosis and desquamation of air-way epithelium and formation of hyaline membranes were obvious in premature rabbi-ts. These results proved that premature rabbits of gestational age 27 days can be used as a model of HMD.

关 键 词：肺透明膜病 动物模型 肺表面活性物质 

分 类 号：R[医药卫生] Q95[生物学—动物学]