低氧照射对小鼠小肠上皮的放射防护效应  

RADIOPROTECTIVE EFFECT OF HYPOXIC IRRADIATION ON INTESTINAL EPITHELIUM OF MICE

作　　者：刘新帆[1] 杨伟志[1] 糜福顺[1] 殷蔚伯[1] 谷铣之[1] 

机构地区：[1]中国医学科学院肿瘤医院

出　　处：《中华放射肿瘤学杂志》1991年第1期47-49,共3页Chinese Journal of Radiation Oncology

摘　　要：精确的实验测定表明:距离毛细血管150～200μm以上的肿瘤细胞氧张力几降为零,显然在氧张力梯度变化的路径上存在有这样的区域,那里的肿瘤细胞既获得有保存致克隆源性足够高的氧分压,而同时这又是抗拒放射损伤足够低的氧分压。这为临床放射治疗带来了麻烦。Comprehensive investigations have suggested that attempt to improve the efficacy of tumor radiotherapy is directed towards the control of hypoxic cells. The partial pressure of oxygen in some of the hypoxic cells is high enough to keep them surviving, while low enough to keep resisting against radiation damage. An increased radical dose should be delivered, but will be limited by the threshold of the tolerance of the normal tissues near the tumor. In the present experiment, using a transient total body hypoxia induced by breathing a gas mixture with 10.5% oxygen, mice were irradiated, and using the yield of destroyed intestinal crypts as criterion of the radiation effect, a radiopro-tective factor (RPF) of 1,37 was obtained. There will be a possibility to permit the administration of an increased tumor dose in clinic trials.

关 键 词：放射防护 低氧 小肠上皮 氧张力 放射损伤 高压氧 放射治疗 空气组 照射量 肠隐窝 

分 类 号：R73[医药卫生—肿瘤]