鼻咽癌患者放射性龋齿的防护——133例前瞻性随机研究  

PREVENTION OF RADIATION CARIES IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA——A prospective randomized trial on 133 patients

作　　者：邱杏仙[1] 赵冠雅 赵森[1] 赵蓉蓉[1] 崔培方 李生惠[2] 

机构地区：[1]上海医科大学附属肿瘤医院 [2]上海第二医科大学附属第九人民医院

出　　处：《中华放射肿瘤学杂志》1991年第2期16-19,共4页Chinese Journal of Radiation Oncology

摘　　要：头颈部恶性肿瘤患者放射治疗后,由于唾液腺泡受损,导致口腔干燥,产生继发的猛性龋,给病人生活带来极大的痛苦,对此病的防治,国内尚缺乏有关资料,为了提高患者的生存质量。The aim of this study was to prevent radiation caries by using fluoride gel and partial shielding of the parotid in radiotherapy for nasopharyngeal carcinoma. 133 patients were entered and randomly divided into four subgroups before irradiation.Group A: fluoride gel and partial parotid shielding, 42 cases.Group B: fluoride gel alone, 29 cases.Group C: partial parotid shielding alone 32 cases.Group D: No fluoride or parotid shielding 30 cases.All patients were followed for two years after the completion of radiotherapy. Our data showed that the increase in mean DMFT (decayed, missing or filled permanent teeth) in group A and group B as compared with group D decreased by 81.4% and 74.6% respectively (A and B vs D, P<0.001) . The increase in mean DMFS (decayed, missing or filled tooth surfaces) in groups A and B as compared with group D decreased by 88.3% and 85% respectively (A and B vs D, P<0.001) . However, the difference of the mean value of DMFT and DMFS between groups C and D was not significant. In conclusion, the neutral fluoride gel (F-concentration of 0.45%) , but not partial parotid shielding was effective in the prevention of caries in head and neck malignancy patients undergoing radiotherapy.

关 键 词：放射性龋齿 头颈部恶性肿瘤 猛性龋 口腔干燥 随机研究 放射治疗 挡铅 生存质量 头颈部肿瘤 患龋率 

分 类 号：R73[医药卫生—肿瘤]