新型有机锗化合物的放射增敏剂研究  

STUDY ON RADIOSENSITIZING EFFECT IN NEW COMPOUNDS OF ORGANIC GERMANIUM (Ge)

作　　者：糜福顺[1] 李政[1] 沈瑜[1] 李美佳[2] 王荣光 胡璧[2] 

机构地区：[1]中国医学科学院肿瘤研究所 [2]中国医学科学院放射医学研究所

出　　处：《中华放射肿瘤学杂志》1991年第2期49-51,共3页Chinese Journal of Radiation Oncology

基　　金：国家"七五"攻关项目

摘　　要：在广泛研究MISO的基础上,英美学者相继合成了RSU-1069,SR-2508及R₀-03-8799。前者放射增敏效果优于Miso,但毒性相应Miso大10倍,后两者毒性虽然低于或等于Miso。The radiosensitizing effect and cytotoxicity of 3 compounds of organic germanium (Ge) on Hela-S3 cell line were investigated, using cell colony forming assay in vitro. The results showed that ID50 was 10.92 mM, 8.56 mM, and 13.04 mM respectively for S-8927, S-8929 and S-8930. When the concentration of these compounds was 1/5 ID50, sensitive enhancement ratio (SER) of hypoxic cells was 1.34, 1.68 and 1.52 respectively. SER of 1.21, 1.61 and 1.47 were obtained for 1/10 ID50. It shows that these 3 compounds of organic germanium are very potential radiosensitizers of hypoxic cells by having low cytotoxicity and stronger effect.

关 键 词：放射增敏剂 有机锗化合物 乏氧细胞 亲肿瘤化合物 放射增敏作用 多靶单击模型 克隆形成 英美学者 放射增敏试验 照射野 

分 类 号：R73[医药卫生—肿瘤]