EFFECTS OF BAICALEIN, WOGONIN, BAICALIN AND Na2MoO_4 ON N-NITROSATION REACTION  

作　　者：Yu FANG, Dao Dao HU, Zi Li ZHAO, Yun Chao MA and Zuo Min SUN Department of Chemistry, Shanxi Normal University, Xi’an, 710062 Zhi Quan CAO Beijing College of Traditional Chinese Medicine, Beijing, 100029 

出　　处：《Chinese Chemical Letters》1991年第10期823-826,共4页中国化学快报（英文版）

摘　　要：The in vitro effects of baicalein,wogonin,baicalin and Na_2MoO_4 on N-nitrosation reaction have been studied. The N-nitrosation reaction has been determined by the amount of dimethylnitrosamine(DMN) and diethylnitrosamine(DEN) produced using the UV-photclysis spectrophotometric and pyrolysis gas chromatography test. Baicalein,wogonin and Na_2MoO_4 showed varing extents of inhibition of the formation of DMN and DEN. Baicalin promoted the formation of DMN and DEN under the condition of simulating gastric Juices. It is also found that E. coli showed a remarkable promoting effect on the formation of DMN and DEN,but this promoting effect could be blocked to some extent by baicalein,wogonin,baicalin and Na_2MoO_4. Besides, Na_2MoO_4 and wogonin have shown synergic effect on the blocking of N-nitrosation reaction.The in vitro effects of baicalein,wogonin,baicalin and Na_2MoO_4 on N-nitrosation reaction have been studied. The N-nitrosation reaction has been determined by the amount of dimethylnitrosamine(DMN) and diethylnitrosamine(DEN) produced using the UV-photclysis spectrophotometric and pyrolysis gas chromatography test. Baicalein,wogonin and Na_2MoO_4 showed varing extents of inhibition of the formation of DMN and DEN. Baicalin promoted the formation of DMN and DEN under the condition of simulating gastric Juices. It is also found that E. coli showed a remarkable promoting effect on the formation of DMN and DEN,but this promoting effect could be blocked to some extent by baicalein,wogonin,baicalin and Na_2MoO_4. Besides, Na_2MoO_4 and wogonin have shown synergic effect on the blocking of N-nitrosation reaction.

关 键 词：DEA Na EFFECTS OF BAICALEIN WOGONIN BAICALIN AND Na2MoO4 ON N-NITROSATION REACTION DMN 

分 类 号：O6[理学—化学]