WOGONIN

作品数：20被引量：204H指数：7
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相关领域：医药卫生更多>>
相关作者：杨晓静胡春丽徐晓珍王冬梅冯锋更多>>
相关机构：中国药科大学沈阳药科大学中国农业科学院特产研究所海南医学院更多>>
相关期刊：《Journal of Future Foods》《Acta Biochimica et Biophysica Sinica》《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金中国博士后科学基金安徽省自然科学基金福建省自然科学基金更多>>
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Identification of novel targets and mechanisms of wogonin on lung cancer,bladder cancer,and colon cancer
《Journal of Future Foods》2024年第3期267-279,共13页Lin Zhou Yunran Hu Changxing Gao Congci Yu Zhiting Sun Weihong Ge Hui Yang 
supported by the Fundamental Research Funds for the Central Universities(3332022085,3332022083,3332022084);the National Natural Science Foundation of China(82204720)。
Wogonin(WOG)has been demonstrated to have anti-cancer activity,but the mechanisms remain unclear.In this study,new targets of WOG were predicted for lung cancer,bladder cancer,and colon cancer by using bioinformatics ...
关键词：WOGONIN TARGETS Lung cancer Bladder cancer Colon cancer 
Author Correction:Wogonin suppresses osteopontin expression in adipocytes by activating PPARα
《Acta Pharmacologica Sinica》2023年第6期I0001-I0001,共1页Ye-min Zhang Ming-xin Li Zhao Tang Chang-hua Wang 
Correction to:Acta Pharmacologica Sinica https://doi.org/10.1038/aps.2015.37,published online 15 June 2015 The authors are very sorry for two mistakes in the figures:the images of western blot showing PPARαphosphoryl...
关键词：PPARΑ process. submission 
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease被引量：46
《Acta Pharmacologica Sinica》2022年第1期96-110,共15页Xue-qi Liu Ling Jiang Yuan-yuan Li Yue-bo Huang Xue-ru Hu Wei Zhu Xian Wang Yong-gui Wu Xiao-ming Meng Xiang-ming Qi 
The authors thank the Center for Scientific Research of Anhui Medical University for valuable help in our experiment.This study was supported by the Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province(no.2017zhyx01);the Promotion Plan of Basic and Clinical Cooperative Research in Anhui Medical University(No.2019xkjT014);and Natural Science Research Project of Universities in Anhui Province(no.KJ2018A0493).
Diabetic kidney disease(DKD)is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options.Wogonin is a flavonoid derived from the root of Sc...
关键词：diabetic kidney disease WOGONIN PODOCYTES AUTOPHAGY APOPTOSIS BCL-2 
LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis被引量：1
《Acta Pharmacologica Sinica》2021年第2期290-300,共11页Xiao-xuan Yu Meng-yuan Zhu Jia-rong Wang Hui Li Po Hu Ying-jie Qing Xiang-yuan Wang Hong-zheng Wang Zhan-yu Wang Jing-yan Xu Qing-long Guo Hui Hui 
supported by the National Natural Science Foundation of China(81873046,81830105,81903647,81503096,and 81673461);the Drug Innovation Major Project(2017ZX09301014,2018ZX09711001-003-007,and 2017ZX09101003-005-023);Natural Science Foundation of Jiangsu Province(BK20190560 and BE2018711);Nanjing Medical Science and Technology Development Project(YKK17074);Research and Innovation Project for College Graduates of Jiangsu Province(KYCX18_0803);China Postdoctoral Science Foundation(No.2018M642373);Double First-Class"University project(CPU 2018GF11 and CPU2018GF05).
Cutaneous T-cell lymphoma(CTCL)is characterized by a heterogeneous group of extranodal non-Hodgkin lymphomas,in which monoclonal T lymphocytes infiltrate the skin.LW-213,a derivative of wogonin,was found to induce cel...
关键词：CTCL LW-213 WOGONIN flavonoids ER stress ROS calcium apoptosis NAC 2-APB 
Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis被引量：13
《Bone Research》2020年第1期84-96,共13页Sirong Shi Yang Chen Taoran Tian Songhang Li Shiyu Lin Yuxin Zhang Xiaoru Shao Tao Zhang Yunfeng Lin Xiaoxiao Cai 
supported by National Key R&D Program of China (2019YFA0110600);National Natural Science Foundation of China (81970986, 81771125)
Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To slow or reverse its progression, ...
关键词：COMPLEXES TETRAHEDRAL promoted 
The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis被引量：32
《Molecular Plant》2019年第7期935-950,共16页Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin 
National Key R&D Program of China (2018YFC1706200,2018YFD1000701-4);the National Natural Science Foundation of China (31870282, 31700268 and 31788103);the Fund of Chinese Academy of Sciences (QYZDY-SSW-SMC026 and 153D31KYSB20160074);the Chenshan Special Fund for Shanghai Landscaping Administration Bureau Program (G182401, G172402, G182402, G192413, and G192414);the CAS/JIC and Center of Excellence for Plant and Microbial Sciences (CEPAMS) joint foundation through support to Q.Z., X.Y.C., J.Y., and C.M. Q.Z. and J.Y. were also supported by the Youth Innovation Promotion Association, Chinese Academy of Sciences.
Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,"Huang Qin," are used for liver and lung complaints and as complementary cancer treatments. We report a hig...
关键词：GENOME skullcap 4’-deoxyflavone traditional Chinese medicine HUANG Qin:evolution specialized METABOLISM 
Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway被引量：1
《Chinese Medical Journal》2018年第4期495-497,共3页Pei-Pei Xu Hua-Qin Zuo Rong-Fu Zhou Bing Chen Jian Ouyang 
To the Editor： Mantle cell lymphoma （MCL） is a non-Hodgkin＇s lymphoma （NHL） subtype and considered one of the most aggressive lyrnphomas with worse prognosis than other subtypes ofN H L. Despite the great progre...
Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4＇-Deoxyflavones in Scutellaria baicalensis被引量：41
《Molecular Plant》2018年第1期135-148,共14页Qing Zhao Meng-Ying Cui Olesya Levsh Dongfeng Yang Jie Liu Jie Li Lionel Hill Lei Yang Yonghong Hu Jing-Ke Weng Xiao-Ya Chen Cathie Martin 
Baicalein, wogonin, and their glycosides are major bioactive compounds found in the medicinal plant Scutellaria baicalensis Georgi. These flavones can induce apoptosis in a variety of cancer cell lines but have no eff...
关键词：Scutellaria baicalensis Huangqin BAICALEIN WOGONIN flavone 6-hydroxylase flavone 8-hydroxylase 
Response of human non-small-cell lung cancer cells to the influence of Wogonin with SGK1 dynamics被引量：2
《Acta Biochimica et Biophysica Sinica》2017年第4期302-310,共9页Guanglin Shi Qian Wang Xiaoyu Zhou Jun Li Hua Liu Jun Gu Haiying Wang Yi Wu Liang Ding Songshi Ni Zhiyuan Tang 
This work was supported by the grants from the National Natural Science Foundation of China （No. 81503143）, Chinese Postdoctoral Science Foundation （No. 2015M581846）, Six Talent Peaks Project in Jiangsu Province （No. 2015-WSN-062）, Key Technology Research of Nantong--People＇s Livelihood （No. MS22015113）, and the Research Innovation Program for College Graduates of Jiangsu Province （No. YKC15081）.
A number of significant studies in the field of cell biology have revealed another pattern of intracellu- lar signal transduction in which cells transmit information through the dynamics of key signaling molecules. Dy...
关键词：S6K1 NSCLC dynamic cell response 
Increased life-span of Drosophila melanogaster by Flavonoids from Scutellariabaicalensis Georgi induced by hydrogen peroxide
《TMR Integrative Medicine》2017年第3期79-85,共7页Dan-Dan Duan Li Gao Xue-Ling Zhang Jian-Qin Zhang Xue-Mei Qin Guan-Hua Du 
This project was supported by the National Natural Science Foundation of China （81603319）, and partlysupported by Programs of Science and Technology and Higher Education of Shanxi Province （2015118）, Scienceand Technology Innovation Team of Shanxi Province （201605D131045-18）, and Key laboratory of EffectiveSubstances Research and Utilization in TCM of Shanxi province （201605D111004）.
Objective： To explore the effects and mechanisms of flavonoids from Scutellaria baicalensis Georgi in hydrogenperoxide （H2O2） induced Drosophila melanogaster model. Method： H2O2 induced Drosophila melanogaster agi...
关键词：BAICALEIN WOGONIN Life-span Hydrogen peroxide Drosophila melanogaste 
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