PODOCYTES

作品数：44被引量：179H指数：8
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相关领域：医药卫生更多>>
相关作者：金娟梁世凯何强李一乔陈舟更多>>
相关机构：浙江省人民医院第二军医大学昆明医科大学大连医科大学更多>>
相关期刊：《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《World Journal of Diabetes》《World Journal of Pediatrics》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Current understanding of adult nephrotic syndrome:Minimal change disease
《World Journal of Nephrology》2025年第1期149-152,共4页Krishna Kumar Govindarajan 
The underlying molecular changes that result in minimal change disease(ne-phrotic syndrome)require an in-depth analysis.Current molecular studies have shown the involvement of zinc fingers and homeobox transcriptional...
关键词：Minimal change disease Nephrotic syndrome Hyposialylation PODOCYTES ALBUMINURIA 
Linggui Zhugan Decoction Improves High Glucose-Induced Autophagy in Podocytes
《Chinese Medical Sciences Journal》2024年第3期193-202,共10页Yuan-Yuan Wang Jian Qin Ru-Lan Zhang Min-Ji Yu Ming-Hua Jin 
supported by Guangdong Bureau of Traditional Chinese Medicine (20211082)
Objective To explore the influence of Linggui Zhugan Decoction(LGZGD) on high glucose induced podocyte autophagy.Methods LGZGD containing serum was prepared by intragastric administation of 4.2 g/kg(low dose), 8.4 g/k...
关键词：diabetic nephropathy PODOCYTE Linggui Zhugan decoction APOPTOSIS AUTOPHAGY 
Effect of Dapagliflozin on cell proliferation, apoptosis and inflammation of podocytes induced by high glucose via regulating p38 MAPK pathway
《China Medical Abstracts(Internal Medicine)》2024年第2期93-94,共2页王东 
Objective To investigate the effect of Dapagliflozin on high glucose-induced podocyte proliferation and apoptosis through p38 mitogen-activated protein kinase(p38 MAPK)pathway.Methods Human glomerular podocytes(HGPC)w...
关键词：APOPTOSIS P38 CASPASE 
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
《Acta Pharmacologica Sinica》2024年第5期1019-1031,共13页Fu-wen Zuo Zhi-yong Liu Ming-wei Wang Jun-yao Du Peng-zhong Ding Hao-ran Zhang Wei Tang Yu Sun Xiao-jie Wang Yan Zhang Yu-sheng Xie Ji-chao Wu Min Liu Zi-ying Wang Fan Yi 
supported by the National Natural Science Foundation of China(T2321004,91949202,82090024,81873614,82090021,81900621,81970580,82070753,82170734,81800645,81800643,22107058);Shandong Provincial Natural Science Foundation,China(ZR2019ZD40,ZR2019MH041,2023HWYQ-020);The Taishan Scholars Program of Shandong Province,China(tsqn202306074);Cutting Edge Development Fund of Advanced Medical Research Institute(GYY2023QY01).
Podocyte lipotoxicity mediated by impaired cellular cholesterol efflux plays a crucial role in the development of diabetic kidney disease(DKD),and the identification of potential therapeutic targets that regulate podo...
关键词：CCDC92 proteasome activity PODOCYTES cholesterol efflux diabetic kidney disease 
Qizhi Jiangtang capsule(芪蛭降糖胶囊)activates podocyte autophagy in diabetic kidney disease by inhibiting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways被引量：1
《Journal of Traditional Chinese Medicine》2023年第4期667-675,共9页GUO Zhaoan SUN Lina LIU Yingying LI Ruifeng LIU Chong DIAO Ke SHI Jing SUN Jun 
National Natural Science Foundation of China Project:Experimental Research on Podocyte Autophagy of Diabetic Nephropathy Regulated by Qizhi Jiangtang Capusul(No.81874440);Natural Science Foundation of Shandong Province Project:Curcumin Ameliorates Diabetic Nephropathy via Regulating the Intestinal Barrier-Inflammation“cross-talk”(ZR2020QH063)。
OBJECTIVE:To investigate the therapeutic action and mechanism of the Qizhi Jiangtang capsule(芪蛭降糖胶囊,QZJT)on diabetic kidney disease(DKD)treatment.METHODS:This experiment used db/db mice and podocytes(MPC5)to dev...
关键词：diabetic kidney disease PODOCYTES AUTOPHAGY AKT Qizhi Jiangtang capsule 
Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway被引量：3
《Current Medical Science》2023年第4期696-707,共12页Tian-qi ZHAO Yuan LI Miao ZHANG Meng-chao ZHAO Xue CAO Shao-zhang HOU 
supported by the Natural Science Foundation of Ningxia Province(No.2021AAC03296).
Objective:Diabetic nephropathy is one of the most important microvascular complications of diabetes,which mainly refers to glomerular capillary sclerosis.Podocytes are an important part of glomerular capillaries.Previ...
关键词：PODOCYTE glomerular fibrosis glycyrrhizic acid diabetic nephropathy AMPK SNARK 
Stigma maydis polysaccharides protect podocyte injury by reducing oxidative stress and apoptosis
《Food Bioscience》2023年第3期1940-1950,共11页Xizhu Wang LuYue Huang Yan Qi Tie cheng Ma Songyi Lin 
financial support provided by the National Key Research and Development Program of China(2017YFD0400504).
Membranous nephropathy(MN)is a glomerulonephritis that has an C5b-9-mediated podocyte injury as its main feature.Stigma maydis polysaccharides(SMP)demonstrate a protective role against podocyte injury in vivo.However,...
关键词：Stigma maydis Corn silk POLYSACCHARIDE Membranous nephropathy PODOCYTES C5B-9 
Corrigendum to “Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs)” [Genes & Diseases 5 (2018) 137–149]
《Genes & Diseases》2023年第2期630-631,共2页Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C. Haydon Hue H. Luu Tong-Chuan He Hua Gan 
The authors regret having an image assembly error in Figure 3A,in which the image for "imPOD Synaptopodin DAPl stain"groupwas erroneouslyduplicatedwiththe imagefrom the"tsPOD-33C SynaptopodinDAPIstain"group.We confirm...
关键词：COR cytes glomerular 
Total flavonoids of Scutellaria barbata improving podocyte injury induced by high glucose through Smad4/PKM2/HIF‑1α pathway
《Journal of Hainan Medical University》2023年第2期22-28,共7页YAN Dong GU Chang‑rui ZHANG Xiang 
Heilongjiang Traditional Chinese Medicine Research Project (No.ZHY19?058)。
Objective: To observe the effect of total flavonoids of Scutellaria barbata (TF‑SB) on the injury of high glucose induced podocytes (MPC‑5) and the influence of Smad4/PKM2/HIF‑1α pathway. Methods: Firstly, CCK8 was u...
关键词：TF‑SB Diabetes nephropathy PODOCYTES Smad4/PKM2/HIF‑1αsignal path 
Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment被引量：3
《Nano Research》2022年第4期3556-3568,共13页Qingsi Wu Jiading Wang Yuanfang Wang Ling Xiang Yulu Tan Jiaxing Feng Zhirong Zhang Ling Zhang 
This work was supported by the Regional Innovation and Development Joint Fund(No.U20A20411);the National Science Fund for Excellent Young Scholars(No.82022070).
The etiology of chronic kidney disease(CKD)is complex and diverse,which could be briefly categorized to glomerular-or tubularoriginated.However,the final outcomes of CKD are mainly glomerular sclerosis,endothelial dys...
关键词：CELASTROL chronic kidney disease(CKD) GLOMERULUS endothelial cells VCAM-1 
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