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作品数：810被引量：2192H指数：18
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Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells
《Genes & Diseases》2025年第3期80-83,共4页Yang Wang Naijipu Abuduaini Wenjuan Liu Yuanjun Song Zunping Ke Xilong Wang Wei Jiao Si Chen Xianhua Lin Weiwei Yu Weiqiang Lu Bo Feng Jiacheng He 
supported by the Shanghai Key Medical Specialty Program(China)(No.ZK2019A03 to Y.W.);Natural Science Research Funds of Minhang District,Shanghai,China(No.2021MHZ071 to Y.W.);Scientific Research Project funded by Shanghai Fifth People’s Hospital,Fudan University(No.2020WYZT02 to Y.W.);the National Natural Science Foundation of China(No.82373237 to B.F.,82172644 to W.Q.L);ECNU Multifunctional Platform for Innovation(011);The Instruments Sharing Platform of School of Life Science,East China Normal University.
Myeloid-derived suppressor cells(MDSCs)constitute a crucial component of the immunosuppressive tumor microenvironment.1 Prostaglandin E2 receptor 4(EP4)is involved in regulating immunosuppressive MDSC differentiation ...
关键词：myeloid derived suppressor cells prostaglandin e receptor MDSCS cancer immunotherapy EP prostaglandin e receptor ep g protein SHIKONIN 
In Search of New Pharmacological Targets:Beyond Carnosine’s Antioxidant,Anti-Inflammatory,and Anti-Aggregation Activities
《BIOCELL》2025年第4期563-578,共16页Giuseppe Carota Lucia Di Pietro Vincenzo Cardaci Anna Privitera Francesco Bellia Valentina DiPietro Giuseppe Lazzarino Barbara Tavazzi Angela Maria Amorini Giacomo Lazzarino Giuseppe Caruso 
Carnosine(β-alanyl-L-histidine)is a naturally occurring endogenous peptide widely distributed in excitable tissues,such as the heart and brain.Over the years,several beneficial effects of carnosine have been discusse...
关键词：CARNOSINE pharmacological targets nitric oxide TGF-β1 FRACTALKINE insulin-degrading enzyme N-METHYLTRANSFERASE energy metabolism 
Exosomal miR-137-3p targets UBE3C to activate STAT3,promoting migration and differentiation into endometrial epithelial cell of human umbilical cord mesenchymal stem cells under hypoxia
《World Journal of Stem Cells》2025年第4期48-63,共16页Wan-Yu Zhang Si-Miao Liu Han-Bi Wang Cheng-Yan Deng 
Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-080 and No.2022-PUMCH-C-064.
BACKGROUND Thin endometrium,leading cause of recurrent implantation failure and infertility,has been found to respond to exosomes.AIM To investigate the efficacy of exosomes in addressing the issue of thin endometrium...
关键词：Endometrial epithelial cells EXOSOMES miR-137-3p Ubiquitin protein ligase E3C Signal transducer and activator of transcription 3 Human umbilical cord mesenchymal stem cells 
Identification of a TOR signaling pathway gene as a candidate target for reproductive management of Adelphocoris suturalis
《Journal of Integrative Agriculture》2025年第4期1529-1541,共13页Wanying Zheng Panyang Jiao Xiaona Xu Weihua Ma J.Joe Hull Hongxia Hua Lizhen Chen 
supported by the National Natural Science Foundation of China(32072428)。
Adelphocoris suturalis is a polyphagous pest that is increasingly causing severe economic damage due to more frequent outbreaks.The development of non-target resistance to commercial Bacillus thuringiensis(Bt)cotton h...
关键词：Adelphocoris suturalis target of rapamycin(TOR)signaling reproductive regulation RNAi targets nanocarrier-mediated RNAi 
Intracellular calcium channels:Potential targets for type 2 diabetes mellitus?
《World Journal of Diabetes》2025年第4期37-47,共11页Jia-Xuan Zhu Zhao-Nan Pan Dan Li 
Supported by Calygene Biotechnology Inc.,No.XT[2016]008@。
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi...
关键词：Ion channels AMP-activated protein kinase CALCIUM DIABETES Lactic acidosis 
Alpha-lipoic acid targets KLF7 expression to inhibit cervical cancer progression
《Acta Biochimica et Biophysica Sinica》2025年第2期237-249,共13页Yi Mao Hongtao Li Gang Xu Jiazhen Tian Yuechan Chen Zhiwei Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.32360825,31960647 and 31501947);the Youth Innovative Talents Project of Shihezi University(Nos.ZZZC202183 and CXBJ201905).
It is unclear what part KLF7 plays in cervical cancer.In this study,immunohistochemical and bioinformatics analyses reveal that KLF7 expression is lower in normal cervical tissues than in cervical cancer tissues,and t...
关键词：cervical cancer Krüppel-like factor 7 alpha-lipoic acid reprogramming of energy metabolism 
Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy
《World Journal of Stem Cells》2025年第2期105-123,共19页Wei Wang Jian Yin 
BACKGROUND Epilepsy is a prevalent chronic neurological disorder affecting 50 million individuals globally,with temporal lobe epilepsy(TLE)being the most common form.Despite advances in antiepileptic drug development,...
关键词：EPILEPSY NEUROINFLAMMATION MiR-203 EXOSOMES Bone marrow mesenchymal stem cells Suppressor of cytokine signaling Nuclear factor kappaB 
Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan
《Science China(Life Sciences)》2025年第2期416-430,共15页Jia-Yu Liu Yao Wang Yue Guo Run-Qi Zheng Yun-Ying Wang Yan-Yan Shen Yan-Hong Liu Ai-Ping Cao Rui-Bo Wang Bo-Yang Xie Shuai Jiang Qiu-Ying Han Jing Chen Fang-Ting Dong Kun He Na Wang Xin Pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-Na Zhang 
supported by the Research Foundation of Nanhu Laboratory(NSS2021CI05003);the National Natural Science Foundation of China(82273024 and 82022030)。
As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly crucial.As an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic...
关键词：tauroursodeoxycholic acid LIFESPAN healthspan protein homeostasis 
Component recognition of ISAR targets via multimodal feature fusion
《Chinese Journal of Aeronautics》2025年第2期256-273,共18页Chenxuan LI Weigang ZHU Wei QU Fanyin MA Rundong WANG 
Inverse Synthetic Aperture Radar(ISAR)images of complex targets have a low Signal-to-Noise Ratio(SNR)and contain fuzzy edges and large differences in scattering intensity,which limits the recognition performance of IS...
关键词：Few-shot Semantic segmentation Inverse Synthetic Aperture Radar(ISAR) SCATTERING Multimodal fusion 
Targets capture by distributed active swarms via bio-inspired reinforcement learning
《Science China(Physics,Mechanics & Astronomy)》2025年第1期206-217,共12页Kun Xu Yue Li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo Li 
supported by the National Natural Science Foundation of China(Grant Nos.12272202,and U22B2042)。
Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals.Learning f...
关键词：swarm intelligence ROBOTICS multi-tasks artificial intelligence BIONICS 
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