云南高校图书馆联盟文献共享服务平台- TARGETS

TARGETS: 作品数：803被引量：2175H指数：18; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郝海平段广仁侯明哲胥彬王兴旺更多>>; 相关机构：北京大学北京理工大学中国药科大学哈尔滨工业大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>

Intracellular calcium channels:Potential targets for type 2 diabetes mellitus?: 《World Journal of Diabetes》2025年第4期37-47,共11页Jia-Xuan Zhu Zhao-Nan Pan Dan Li; Supported by Calygene Biotechnology Inc.,No.XT[2016]008@。; Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi...; 关键词：Ion channels AMP-activated protein kinase CALCIUM DIABETES Lactic acidosis

Exosomal miR-203 from bone marrow stem cells targets the SOCS3/NF-κB pathway to regulate neuroinflammation in temporal lobe epilepsy: 《World Journal of Stem Cells》2025年第2期105-123,共19页Wei Wang Jian Yin; BACKGROUND Epilepsy is a prevalent chronic neurological disorder affecting 50 million individuals globally,with temporal lobe epilepsy(TLE)being the most common form.Despite advances in antiepileptic drug development,...; 关键词：EPILEPSY NEUROINFLAMMATION MiR-203 EXOSOMES Bone marrow mesenchymal stem cells Suppressor of cytokine signaling Nuclear factor kappaB

Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan: 《Science China(Life Sciences)》2025年第2期416-430,共15页Jia-Yu Liu Yao Wang Yue Guo Run-Qi Zheng Yun-Ying Wang Yan-Yan Shen Yan-Hong Liu Ai-Ping Cao Rui-Bo Wang Bo-Yang Xie Shuai Jiang Qiu-Ying Han Jing Chen Fang-Ting Dong Kun He Na Wang Xin Pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-Na Zhang; supported by the Research Foundation of Nanhu Laboratory(NSS2021CI05003);the National Natural Science Foundation of China(82273024 and 82022030)。; As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly crucial.As an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic...; 关键词：tauroursodeoxycholic acid LIFESPAN healthspan protein homeostasis

Component recognition of ISAR targets via multimodal feature fusion: 《Chinese Journal of Aeronautics》2025年第2期256-273,共18页Chenxuan LI Weigang ZHU Wei QU Fanyin MA Rundong WANG; Inverse Synthetic Aperture Radar(ISAR)images of complex targets have a low Signal-to-Noise Ratio(SNR)and contain fuzzy edges and large differences in scattering intensity,which limits the recognition performance of IS...; 关键词：Few-shot Semantic segmentation Inverse Synthetic Aperture Radar(ISAR) SCATTERING Multimodal fusion

Targets capture by distributed active swarms via bio-inspired reinforcement learning: 《Science China(Physics,Mechanics & Astronomy)》2025年第1期206-217,共12页Kun Xu Yue Li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo Li; supported by the National Natural Science Foundation of China(Grant Nos.12272202,and U22B2042)。; Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals.Learning f...; 关键词：swarm intelligence ROBOTICS multi-tasks artificial intelligence BIONICS

ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling: 《Protein & Cell》2025年第1期64-71,共8页Jingdong Xue Siang Lv Ming Yu Yixuan Pan Ningzhe Li Xiang Xu Qi Zhang Mengyuan Peng Fang Liu Xuxu Sun Yimin Lao Yanhua Yao Juan Song Jun Wu Bing Li; supported by the National Key R&D Program of China(2021YFA1300100 to B.L.);the National Natural Science Foundation of China(32030019,31872817 to B.L.,82072892 to J.W.,81901284 to YH.Y.,32000413 to J.S.,31970587,32170609 to X.S.);the Natural Science Foundation of Guangxi(No.2023GXNSFAA026276 to J.W.)。; Dear Editor,The human SWI/SNF chromatin remodeling complexes are essential for modulating genomic architecture and increasing DNA accessibility,thereby regulating gene transcription(Clapier et al.,2017).These complexe...; 关键词：al. REMODELING ARID1A

Ensemble Assessment of Extreme Precipitation Risk under 1.5 and 2.0°C Warming Targets in the Yangtze River Basin: 《Journal of Meteorological Research》2024年第6期1167-1183,共17页Xingguo MO Shuxu YUE Shi HU Suxia LIU; Supported by the National Key Research and Development Program of China(2022YFF0801804 and 2017YFA0603702).; Changes in precipitation extremes and associated risks under the 1.5 and 2.0℃ global warming targets in the Yangtze River basin(YRB)were assessed.The projections from 10 global climate models(GCMs)of the Coupled Mode...; 关键词：Equi-Ratio Cumulative Distribution Functions matching method(ERCDFm) 1.5 and 2.0°C global warming targets extreme precipitation risk ratio Bayesian model averaging Coupled Model Intercom-parison Project phase 6(CMIP6) Yangtze River basin

Zinc metalloprotease FgM35,which targets the wheat zinc-binding protein TaZnBP,contributes to the virulence of Fusarium graminearum: 《Stress Biology》2024年第1期109-125,共17页Xin-tong Wang Kou-han Liu Ying Li Yan-yan Ren Qiang Li Bao-tong Wang; sponsored by National Key R and D Program of China(2023YFD1201002);the Key Research and Development Projects of Shannxi Province(2022NY-125).; Metalloproteinases are ubiquitous in organisms.Most metalloproteinases secreted by pathogenic microorganisms are also called virulence factors,because they degrade proteins in the external tissues of the host,thereby ...; 关键词：Fusarium graminearum FgM35 VIRULENCE Plant immunology Pathogen-Host

Identifying genetic targets in clinical subtypes of Parkinson’s disease for optimizing pharmacological treatment strategies: 《Signal Transduction and Targeted Therapy》2024年第12期5708-5719,共12页Dewen Kong Cao Li LingYan Ma Lida Du Nan Jiang Xiaoyue Zhao Sen Zhang Zhigang Zhao Lianhua Fang Guanhua Du; supported by Beijing Natural Science Foundation(7232258);the CAMS Innovation Fund for Medical Sciences(2022-I2M-1-005);the Key R&D Program of Shan Dong Province(No.2019JZZY020909).; The heterogeneity of Parkinson’s disease(PD)has been recognized in clinical,with patients categorized into distinct subsets based on motor phenotype,such as tremor-dominant PD(TD),postural instability and gait diffic...; 关键词：clinical SUBTYPES alterations

Pathophysiological dynamics in the contact,coagulation,and complement systems during sepsis:Potential targets for nafamostat mesilate: 《Journal of Intensive Medicine》2024年第4期453-467,共15页Qiaolan He Yilin Wei Yiqi Qian Ming Zhong; supported by the National Natural Science Foundation of China(grant numbers 82102287);Key dis-cipline of Shanghai’s Three-year Action Plan to Strengthen the construction of public health system(2023-2025)(grant num-bers GWVI-11.1-14).; Sepsis is a life-threatening syndrome resulting from a dysregulated host response to infection.It is the primary cause of death in the intensive care unit,posing a substantial challenge to human health and medical res...; 关键词：SEPSIS Nafamostat Contact system Coagulation system Complement system

TARGETS