1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR  

作　　者：Zi Li XIAO Ren WEN An Gou MO,Dept.of Medicinal Chemistry,Shanghai Medical University(SMU).Xi Peng JING,Lab.of Isotope,SMU.Feng Yan SUN.Dept.of Neurobiology,SMU,Shanghai 200032. 

出　　处：《Chinese Chemical Letters》1991年第9期677-680,共4页中国化学快报（英文版）

基　　金：Project supported by National Natural Science Foundation of China(No.2870083)

摘　　要：By the condensation of tryptamine with appropriate substituted benzalde- hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo- lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te- traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro.By the condensation of tryptamine with appropriate substituted benzalde- hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo- lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te- traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro.

关 键 词：SUBSTITUTED PHENYL CARBOLINES LTA HCI 

分 类 号：O6[理学—化学]