积雪草提取物对抑郁模型动物行为的影响  

The effect of the extracts of Centella asiatica(L.) Urban(ECU) on the behavior of animal model of depression

作　　者：孙玉红[1] 任美萍[2] 张开莲[1] 刘明华[1] 肖顺汉[1] 

机构地区：[1]泸州医学院药学院,四川泸州646000 [2]泸州医学院药物与功能性食品研究中心,四川泸州646000

出　　处：《中国生化药物杂志》2014年第1期16-18,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：四川省教育厅(2003407;2003A052)

摘　　要：目的观察积雪草提取物对抑郁大鼠、小鼠干预后行为学的改变。方法 60只Wistar大鼠随机分为6组,每组1 0只,分别为对照组、模型组、氟西汀组、积雪草提取物高剂量组(成分10.08mg+成分24.48 mg/kg),中剂量组(成分10.04mg+成分22.24mg/kg),低剂量组(成分10.02 mg+成分21.12 mg/kg)。采用慢性不可预知性温和应激刺激制备大鼠抑郁模型,糖水消耗量检测积雪草提取物抗抑郁效应。60只昆明小鼠,随机分为6组,分组情况同上。自主活动、强迫游泳、悬尾实验检测积雪草提取物对小鼠抑郁样行为的影响。结果积雪草提取物高、中、低剂量组能够明显增加大鼠糖水消耗量,与模型组比较(P<0.01)。积雪草提取物高、中、低剂量组能明显缩短悬尾实验和强迫游泳小鼠不动时间。结论积雪草提取物对大、小鼠抑郁样行为有一定的改善作用。Objective To investigate the effect of the extracts of Centella asiatica(L.) Urban (ECA) on the depressive-like behavior alteration in rats and mice. Method 60 Wistar rats were randomly divided into 6 groups (10 rats each), the normal group, model group, Fluoxetine group, ECA high dose group (component 10.08 mg+component 24.48 mg/kg), ECA middle dose group (component 1 0.04 mg+component 2 2.24 mg/kg) and ECA low dose group component 1 0.02 mg+component 2 1.12 mg/kg. Chronic unpredictable mild stress (CUMS) induced depression in rats and sugar consumption to detect the antidepressant effect of ECU. 60 Kunming mice were randomly divided into six groups as above. Locomotor activity, forced swim, tail suspension test were used to detect the effect of ECA on the behavioral alteration in mice. Results Compared with model group, sugar consumption in ECA groups was significant increased (P<0.01). ECA treatments also decreased duration of immobility in the tail suspension test and forced swim. Conclusion ECA could improve the depressive-like behavior in rats and mice.

关 键 词：积雪草 抑郁症 慢性不可预知温和刺激 

分 类 号：R575[医药卫生—消化系统]