替硝唑治疗加重型口腔感染的近期效果及安全性分析  

Recent clinical efficacy and safety analysis of Tinidazole in treatment of severe oral infection

作　　者：元小平 李立峰 

机构地区：[1]台州市温岭第三人民医院口腔科,浙江台州317523 [2]浙江省富阳市人民医院口腔科,浙江富阳311400

出　　处：《中国生化药物杂志》2014年第2期97-98,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省基层卫生适宜技术转化应用计划B类(2010ZHB001)

摘　　要：目的：研究替硝唑对加重型口腔感染（severe oral infection，SOI）的近期临床疗效及安全性情况。方法选择2012年4月～2013年4月在温岭第三人民医院口腔科确诊为SOI的88例患者，数字随机法分成观察组（n=45）以及对照组（n=43）。对照组予以甲硝唑药物治疗，观察组予以替硝唑药物治疗。对比2组疗效、恢复时长及不良反应情况。结果观察组疗效显著优于对照组，差异有统计学意义（P＜0.05）。观察组症状消失的平均时长为（4.8±0.4）h，伤口的平均愈合时长为（4.3±0.2）h，均显著少于对照组的(5.5±0.2)h，(5.6±0.1)h，差异均有统计学意义（P＜0.05）。治疗组的不良反应低于对照组，差异有统计学意义（P＜0.05）。结论替硝唑用于治疗SOI，疗效显著，且不良反应更弱。Objective To study recent clinical efifcacy and safety analysis of tinidazole and metronidazole in treatment of severe oral infection. Methods, 88 cases with severe oral infection(SOI) collected in the third people''s hospital of Wenling from April 2012 to April 2013 were divided into observation group (n=45) and control group (n=43) by random number table. Control group were received metronidazole drug treatment, while observation group were treated with tinidazole medication, The efifcacy, recovery duration and adverse reactions were compared between two groups. Results The efficacy of observation group was significantly better than control group, the difference was statistically significant (P<0.05). The average duration of symptoms and wound healing in observation group were (4.8±0.4)hs and (4.3 ± 0.2)hs, which were signiifcantly less than (5.5 ± 0.2)sh and (5.6 ± 0.1)sh in control group(P<0.05).Adverse reactions in observation group were signiifcantly lower than that in control group (P<0.05). Conclusion Tinidazole has a signiifcant effect and less adverse reactions in treatment of SOI.

关 键 词：替硝唑 甲硝唑 口腔感染 安全性 

分 类 号：R781.5[医药卫生—口腔医学]