晚期非小细胞肺癌患者应用顺铂化疗后MRP和LRP基因的表达  

Clinical study of MRP and LRP mRNA expression in peple with human non-small cell lung cancer after cisplatin chemotherapy

作　　者：温志军[1] 

机构地区：[1]山东东营胜利油田中心医院胸外科,山东东营257034

出　　处：《中国生化药物杂志》2014年第2期108-109,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：山东省高校科技计划(J11LF75)

摘　　要：目的探讨多药耐药相关蛋白MRP(multidrug resistance associated protein,MRP)和肺耐药相关蛋白(lung resistance protein,LRP)在非小细胞肺癌中的基因表达及与顺铂耐药的关系。方法搜集化疗前后均有标本的非小细胞肺癌患者13例,应用RT-PCR法检测化疗前后MRP和LRP基因表达,Logistic回归分析法分析2种蛋白基因表达的相关性。结果与顺铂化疗前相比,化疗后患者MRP基因和LRP基因表达均显著增高(P<0.05),Logistic回归分析显示,2种蛋白的基因表达不具有相关性(r=O.036.P<0.05)。结论应用顺铂化疗后MRP和LRP基因表达增高,且2种蛋白的基因表达不具有相关性。Objective To investigate the mRNA expression of the multidrug resistance associated protein and lung resistance protein in human non-small cell lung cancer tissues and their relationship with cis-platinum. Methods 13 samples were collected from patients with non small cell lung cancer before and after chemotherapy, the mRNA expression of MRP and LRP were detected using RT-PCR method, correlation between two genes were studied by Logistic regression analysis. Results Compared with before cisplatin chemotherapy, MRP and LRP expression of patients were increased after chemotherapy(P<0.05).Logistic regression analysis showed that there is no correlation between the two genes(r=0.036,P<0.05). Conclusion Cisplatin chemotherapy can increase the mRNA expression of MRP and LRP, and there is no correlation between the two genes.

关 键 词：非小细胞肺癌 顺铂 多药耐药相关蛋白 肺耐药相关蛋白 

分 类 号：R734.2[医药卫生—肿瘤]