癫痫持续状态患儿血清心肌肌钙蛋白I、肌酸激酶变化的临床意义  

The clinical significance of status epilepticus serum cardiac troponin I, creatine kinase changes

作　　者：杨铭华 阚秀梅 孙喜娟 李真真 栾聪颖 

机构地区：[1]黑龙江省哈尔滨市儿童医院检验科,哈尔滨150001

出　　处：《临床检验杂志（电子版）》2014年第1期524-526,共3页Clinical Laboratory Journal(Electronic Edition)

摘　　要：目的探讨癫痫持续状态(status epilepticus,SE)时血清心肌肌钙蛋白I(cardiactroponin I,cTnI)、肌酸激酶同工酶-MB(CK-MB)变化的临床意义。方法测定60例癫痫持续状态患儿癫痫持续发作前和发作后6h血清CK-MB和心肌肌钙蛋白I,并与60例对照组患儿进行比较。结果病例组患儿癫痫持续发作前后血清CK-MB和心肌肌钙蛋白I均明显高于对照组(P<0.01),且发作后高于发作前(P<0.01)。病例组患儿血清CK-MB和心肌肌钙蛋白I阳性率分别为36.7%和26.7%,均高于对照组(P<0.05)。结论癫痫持续状态可引起患儿血清CK-MB和心肌肌钙蛋白I升高,可能与心肌的损伤有关。Objective Discussion of status epilepticus(status epilepticus, SE) serum cardiac troponin I(cardiac troponin I, cTnI), creatine kinase-MB(CK-MB) changes in clinical significance. Methods serum cardiac troponin I(cTnI), creatine kinase isoenzyme MB(CK-MB) were assayed in 60 cases of status epilepticus in children with epilepsy before continuing seizures and 6h after the onset, and with the children in the control group 60 cases. Results Serum CK-MB and cardiac troponin I were significantly higher in children before and after the Patient group group epilepticus seizures(P<0.01), and after the onset of higher than before the onset(P<0.01). Patient group serum CK-MB and cardiac troponin I-positive rate of 36.7% and 26.7%, respectively,were higher(P<0.05). Conclusions Status epilepticus can cause serum CK-MB and cardiac troponin I elevation, and may be associated with myocardial injury.

关 键 词：癫痫持续状态 心肌损伤 心肌肌钙蛋白I 肌酸激酶同工酶-MB 

分 类 号：R742.1[医药卫生—神经病学与精神病学]