人类X射线交错互补修复基因1 Arg399Gln位点多态性与胃癌易患性病例对照研究的Meta分析  

Relationship between XRCC1 Arg399Gln Polymorphism and Gastric Cancer Susceptibility:A Meta Analysis

作　　者：王晓龙[1] 张成武[1] 刘宁[1] 马晓明[1] 

机构地区：[1]青海大学附属医院胃肠外科,青海省西宁市810001

出　　处：《中国全科医学》2013年第27期3216-3220,共5页Chinese General Practice

摘　　要：目的探讨人类X射线交错互补修复基因1(XRCC1)Arg399Gln位点多态性与胃癌易患性的关系。方法检索PubMed、Embase、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、中国期刊全文数据库(CNKI)、万方数据库关于XRCC1多态性与胃癌易患性的病例对照研究,检索日期均从开始建库到2012年10月。收集相关文献后,对文献进行评价筛选。以病例组(胃癌患者)和对照组(健康者)XRCC1 Arg399Gln位点基因型分布的比值比(OR)为效应量来评价XRCC1多态性与胃癌易患性的关系。对纳入的文献进行异质性检验和Meta分析,采用STATA软件进行统计分析。结果最终纳入12篇病例对照研究进行Meta分析,其中病例组2 701例,对照组4 210例。异质性检验显示,XRCC1 Arg399Gln位点杂合子模型(AA与GA)、隐性模型(GG+GA与AA)与胃癌易患性的各研究间无异质性,采用固定效应模型进行Meta分析,合并OR值及95%CI分别为0.98(0.88,1.08)和1.05(0.95,1.16);纯合子模型(AA与GG)、杂合子模型(GA与GG)、显性模型(AA+GA与GG)与胃癌易患性的各研究间存在异质性,采用随机效应模型进行Meta分析,合并OR值及95%CI分别为0.75(0.54,1.05)、0.78(0.54,1.12)和0.74(0.53,1.05)。结论 XRCC1 Arg399Gln位点多态性与胃癌的易患性无关联。Objective To study the relationship between XRCC1 Arg399Gln polymorphism and gastric cancer susceptibility by Meta-analysis.Methods We searched in PubMed,Embase,CBM,VIP,CNKI and Wanfang database to identify case-control studies on the association between XRCC1 Arg399Gln polymorphism and gastric cancer susceptibility,the time ranged for publishing dates of the literatures was from databases establishment to October 2012.The relevant literatures were collected,evaluated and selected.Odds ratio(OR) of XRCC1 Arg399Gln genotype distributions in patients with gastric cancer and healthy controls was calculated and treated as effective variable,by which the relationship between XRCC1 Arg399Gln polymorphism and gastric cancer was evaluated.Heterogeneity test and Meta-analysis were performed among the included literatures,and data was analyzed statistically by STATA software.Results A total of 12 case-control studies were included,with 2 701 cases in case group and 4 210 cases in control group.Heterogeneity test result showed that there was no statistical heterogeneity among studies on relationship between gastric cancer susceptibility and XRCC1 Arg399Gln site heterozygote model(AA and GA),XRCC1 Arg399Gln site recessive model(GG + GA and AA).The fixed effect model was used for Meta-analysis,the pooled OR and 95% CI was 0.98(0.88,1.08) and 1.05(0.95,1.16) respectively.Heterogeneity test result showed that there was statistical heterogeneity among studies on relationship between gastric cancer susceptibility and homozygous model(AA and GG),recessive model(AA and GA),dominant model(AA + GA and GG).The random effect model was used for Meta-analysis,the pooled OR and 95% CI was 0.75(0.54,1.05),0.78(0.54,1.12),0.74(0.53,1.05) respectively.Conclusion There is no relationship between XRCC1 Arg399Gln polymorphism and gastric cancer susceptibility.

关 键 词：胃肿瘤 多态性 单核苷酸 X射线交错互补修复基因1 Arg399Gln META分析 

分 类 号：R735.2[医药卫生—肿瘤]