子宫内膜息肉的研究进展及转化医学  

Research on Endometrial Polyps and Translational Medicine

作　　者：姜璇[1] 金力[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院妇产科,北京100730

出　　处：《国际生殖健康／计划生育杂志》2013年第2期127-131,148,共6页Journal of International Reproductive Health/Family Planning

摘　　要：近年来随着生殖医学和宫腔镜检查的发展,子宫内膜息肉的诊断率显著提高,受到临床的广泛重视。局部内膜的激素受体表达失衡以及细胞增生和凋亡的失衡导致内膜息肉的发病,内膜息肉长期处于雌激素刺激无孕激素对抗的状态,合并有腺体的癌前病变如腺体的不典型增生或内膜上皮内瘤样病变,P21ras蛋白的免疫组化强阳性或PTEN染色区域的缺失、MTP53蛋白的过表达等因素,有可能导致其内膜癌发病风险增高。各项基础研究成果为临床上子宫内膜息肉的诊治提供了大量有价值的提示,为转化医学的实现注入了新的动力。Following the development of reproductive medicine and hysterology,the diagnostic rate of endometrial polyps is highly increased.The unbalanced expression of hormone receptors,and the disordered cell proliferation and apoptosis,may play a role in the pathogenensis of polyps.The long term of estrogen stimulation without progestational hormone,the concomitant endometrial glandular dysplasia or endometrial intraepithelial carcinoma,the strong positive expression of P21ras proteins,the lack of PTEN dyeing area and the overexpression of MTP53 proteins in polyps tissue may be risk factors of endometrial cancers.Those findings provide us a new entry for the therapy of endometrial polyps and a path of translational medicine.

关 键 词：息肉 子宫内膜肿瘤 受体 雌激素 受体 孕酮 原癌基因蛋白质p21(ras) PTEN磷酸水解酶 肿瘤抑制蛋白质P53 转化医学 

分 类 号：R737.33[医药卫生—肿瘤]