诱导化疗和同步放化疗用于中晚期鼻咽癌的比较  

The Efficacy of TPF Induction Chemotherapy and Concurrent Chemoradiotherapy for Advanced Nasopharyngeal Carcinoma

作　　者：袁理[1] 廖垚[1] 

机构地区：[1]绵阳市中心医院,四川绵阳621000

出　　处：《现代临床医学》2013年第6期414-416,共3页Journal of Modern Clinical Medicine

摘　　要：目的:观察TPF方案诱导化疗及同步放化疗在中晚期鼻咽癌中的疗效及毒副反应比较。方法:将56例中晚期(Ⅲ~Ⅳa期)肿瘤患者随机分为诱导化疗组和同步放化疗组,每组各28例。诱导化疗组使用氟尿嘧啶(5-FU)联合紫杉醇(TAX)加顺铂(cisplatin)的TPF方案诱导化疗2个周期,后进行适形调强放疗(IMRT);同步放化疗组同步进行TPF方案化疗2个周期及IMRT,治疗完成后对2组有效性及毒副反应进行比较。结果:2组局部肿瘤控制佳,诱导化疗组总有效率78.57%,同步放化疗组总有效率87.50%,2组比较无显著性差异(P>0.05)。2组均不同程度出现消化道反应、黏膜炎性反应及血液系统毒性反应,同步放化疗组放疗中期出现严重皮肤黏膜反应4例,中止放疗4例,诱导化疗组全部完成放化疗。结论:TPF方案在中晚期鼻咽癌诱导化疗中疗效与同步放化疗相似,但诱导化疗毒性反应相对较小,具有更好的耐受性和可行性。Objective: To compare to the efficacy and the toxicity of TPF induction chemotherapy and concurrent chemoradiotheray for advanced nasopharyngeal carcinoma. Method: 56 patients with advanced nasopharyngeal were randomly divided into two groups. The one were induction chemotherapy group( n = 28), and was treated with IMRT after two cycles of TPF program chemotherapy; other was concurrent therapy group( n =28),and was treated with TPF program chemotherapy and IMRT simultaneously. Compared to the Safety and effectiveness of the two groups after treatments. Results: The local tumors were controlled in two groups that the induction chemotherapy group was 78. 57%; and concurrent therapy group was 87. 50%. the difference was not statistically significant( P > 0. 05). Concurrent therapy group had 4 cases of severe catarrh and derma reaction; 4 cases discontinued radiotherapy. Conclusion: There are similar effective in induction chemotherapy and in concurrent therapy groups. Induction chemotherapy has high safety and is suitable for clinical application.

关 键 词：鼻咽癌 诱导化疗 同步放化疗 

分 类 号：R739.63[医药卫生—肿瘤]