生化止血饮对药流后蜕膜中PR和LN表达影响的临床实验研究  

Clinical research on the effect of the Shenghua Zhixue decoction on the expression of PR and LN in decidua

作　　者：李文清[1] 于燕[2] 王丽[1] 

机构地区：[1]黑龙江中医药大学研究生学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医临床研究》2013年第24期16-18,共3页Clinical Journal Of Chinese Medicine

基　　金：教育部春晖计划;编号:Z2009-1-15020

摘　　要：目的:通过观察生化止血饮对药物流产后蜕膜中孕激素受体(Progesterone Receptor,PR)和层黏连蛋白(Laminin,LN)表达的影响,研究中药防治药物流产后子宫出血的机制。方法:选取自愿药物流产终止妊娠者80例,临床分为人工流产组、单纯药物流产组、益母草组、生化止血饮组,每组20例,留取新鲜蜕膜组织,运用免疫组织化学法,观察各组表达的情况。结果:生化止血饮组蜕膜中PR和LN的表达明显低于其他三组,差异具有显著性(P<0.05)。结论:生化止血饮可以下调药流后蜕膜组织中PR的表达水平,抑制蜕膜细胞分泌LN,降低蜕膜细胞与子宫内膜组织的粘附作用,促使残留蜕膜组织排出,达到减轻药流后出血的目的,使药流完全。Objective:To investigate the Shenghua Zhixue decoction after medical abortion the expression of PR and LN, to study mechanisms of TCM in preventing uterine bleeding after medical abortion. Methods: 80 cases of medical abortion were divided into induced abortion group, simple medical abortion group, motherwort group, Shenghua Zhixue decoction group, 20 cases in each group. Taking fresh decidua and using immunohistochemical method, to observe the situation of expression in each group. Results:PR and LN of Shenghua Zhixue decoction group were significantly lower than the other three groups, the difference was significant (P<0.05). Conclusion:Shenghua Zhixue decoction can lower slough membrane tissue expression levels of PR after medical abortion, inhibiting decidual cell secretion of LN, reduce the adhesion of decidual cells and and endometrial tissue, induce the discharge of residual decidua, achieving the purpose to reduce bleeding, so that the medical abortion is completed.

关 键 词：中药防治 药物流产后出血 蜕膜组织 PR LN 

分 类 号：R271.41[医药卫生—中医妇科学]