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LN: 作品数：1728被引量：4088H指数：22; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：牛淑云金晶范玉华毕彩丰迟玉贤更多>>; 相关机构：中国科学院吉林大学北京大学辽宁师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家重点实验室开放基金广东省自然科学基金更多>>

Phosphorylation-related genes in lupus nephritis:Single-cell and machine learning insights: 《Genes & Diseases》2025年第3期31-34,共4页Lisha Mou Zhihao Chen Xinran Tian Yupeng Lai Zuhui Pu Meiying Wang; supported by the Science and Technology Program for Basic Research in Shenzhen,Guangdong,China(No.JCYJ20200109140412476,JCYJ20190809095811254,GCZX2015043017281705);the Clinical Research Project in Shenzhen,Guangdong,China(No.20213357002,20213357028);the Team-based Medical Science Research Program in Shenzhen,Guangdong,China(No.2024YZZ06);Shenzhen High-level Hospital Construction Fund in Shenzhen,Guangdong,China(No.2024).; This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this c...; 关键词：nonnegative matrix factorization nmf algorithmwe machine learning renal tissues lupus nephritis critical gene patterns single cell RNA sequencing lupus nephritis ln phosphorylation related genes

长链非编码RNA AC087388.1靶向PABPC1对食管鳞癌作用机制: 《中国药理学通报》2025年第5期926-935,共10页仲瀚戈艳蕾甘俊清金叶郑璇刘子情孙国贵; 国家自然科学基金面上项目(No 82472636);河北省创新能力提升计划项目(No 235A2403D);河北省教育厅河北实验教学及教学实验室建设项目(No 81);华北理工大学公共卫生学院高水平科研创新团队建设计划(No KYTD202309)。; 目的探讨长链非编码RNA(long non-coding RNA,lncRNA)AC087388.1和细胞质多聚腺苷酸结合蛋白1(poly(A)binding protein cytoplasmic 1,PABPC1)在食管鳞癌(esophageal squamous cell carcinoma,ESCC)中的作用与机制。方法采用实时荧光定...; 关键词：食管鳞状细胞癌 lnc-AC087388.1 细胞质多聚腺苷酸结合蛋白1 增殖迁移侵袭

长链非编码lnc-FAF通过调控微小RNA-302a-3p保护缺氧复氧诱导肾小管上皮细胞的损伤: 《陕西医学杂志》2025年第4期452-457,共6页王兴健周巧艳颜伟健胡超; 国家自然科学基金资助项目(81900682)。; 目的:探讨长链非编码(lncRNA)lnc-FAF对缺氧复氧诱导肾小管上皮细胞损伤的影响及调控机制。方法:对HK-2细胞进行缺氧复氧处理,建立HK-2细胞损伤模型,实时定量聚合酶链反应(qRT-PCR)检测HK-2细胞中lnc-FAF表达。采用慢病毒感染技术上调H...; 关键词：长链非编码RNA lnc-FAF 肾小管上皮细胞微小RNA-302a-3p 缺氧复氧细胞凋亡

构建元素相同晶相不同的Ln_(2)Zr_(2)O_(7)(Ln=Pr,Nd,Sm)催化剂用于甲烷氧化偶联反应: 《南昌大学学报(工科版)》2025年第1期1-13,共13页王翔欧阳汝梦徐骏伟钟旭升周杰祺; 江西省自然科学基金资助项目(20224BAB213017);国家自然科学基金资助项目(22172071,22102069,22376090)。; 采用简单的共沉淀法通过不同焙烧温度制备了3组不同晶相结构和晶格无序度的Ln_(2)Zr_(2)O_(7)(Ln=Pr,Nd,Sm)复合氧化物催化剂,用于探究其对甲烷氧化偶联反应的影响。结果表明:A_(2)B_(2)O_(7)复合氧化物的化学组成相同、晶相结构和晶格...; 关键词：甲烷氧化偶联反应 A_(2)B_(2)O_(7)复合氧化物晶相结构晶格无序度活性氧中心碱中心

LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC: 《World Journal of Diabetes》2025年第3期146-166,共21页Yi-Yi Luo Xue-Ying Ba Ling Wang Ye-Pin Zhang Hong Xu Pei-Qi Chen Li-Bo Zhang Jian Han Heng Luo; Supported by Science and Technology Program of Yunnan Provincial Department of Science and Technology-Basic Research Program,No.202301BA070001-025.; BACKGROUND Diabetic retinopathy(DR)is one of the major eye diseases contributing to blindness worldwide.Endoplasmic reticulum(ER)stress in retinal cells is a key factor leading to retinal inflammation and vascular lea...; 关键词：Diabetic retinopathy Endoplasmic reticulum stress miR-495-3p/GRP78 Lnc-MGC Retinal pigment epithelium cells Ferroptosis

Unlocking the Therapeutic Applicability of LNP-mRNA:Chemistry,Formulation,and Clinical Strategies: 《Research》2025年第1期450-476,共27页Xiaonan Huang Yishan Ma Guanghui Ma Yufei Xia; supported by the National Key Research and Development Program of China(2022YFE0202500);Distinguished Young Scholars of the National Natural Science Foundation of China(grant no.T2222022);National Key Research and Development Program of China(2021YFC2302402 and 2021YFC2302605);Major Program of the National Natural Science Foundation of China(grant no.T2394503);Key Project of the National Natural Science Foundation of China(grant no.32030062);CAS Project for Young Scientists in Basic Research(YSBR-010);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(grant no.21821005);Youth Innovation Promotion Association of the Chinese Academy of Sciences(no.2020000053).; Messenger RNA(mRNA)has emerged as an innovative therapeutic modality,offering promising avenues for the prevention and treatment of a variety of diseases.The tremendous success of mRNA vaccines in effectively combatti...; 关键词：therapeutic applicability lipid nanoparticles lnps clinical strategies messenger rna mrna

LN-439A,a novel BAP1 inhibitor,suppresses the growth of basal-like breast cancer by degrading KLF5: 《Acta Pharmacologica Sinica》2025年第3期715-727,共13页Tian-tian Wang Long-long Zhang Fu-bing Li Jie Zhang Zhi-bi Zhang Da-zhao Mi Jian Sun Hong-yan Zhang Chun-yan Wang Yi-hua Chen Ce-shi Chen; supported by National Key Research and Development Program of China(2020YFA0112300,2023YFA1800403);the National Natural Science Foundation of China(U2102203,82260691,82160461,82472806);the Biomedical Projects of Yunnan Key Science and Technology Program(202302AA310046);the Yunnan Revitalization Talent Support Program(Yunling Shcolar Project to CC),Yunnan(Kunming)Academician Expert Workstation(YSZJGZZ-2020025 to CC);the Key Research and Development Program of Ningxia(2023BEG02010);the Yunnan Fundamental Research Projects(202401AT070171);the Technology Innovation Team of Pathological Diagnosis of Triple Negative Breast Cancer in Kunming Medical University(grant number CXTD202208);Yunnan Revitalization Talent Support Program,Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University(202401AY070001-026).; Basal-like breast cancer(BLBC)is the most malignant subtype of breast cancer because of its aggressive clinical behaviour and lack of effective targeted agents.Krüppel-like factor 5(KLF5)is an oncogenic transcription...; 关键词：BLBC LN-439A KLF5 BAP1 DEUBIQUITINATION

全球LN G运输市场2024年回顾及2025年展望: 《世界海运》2025年第2期16-22,共7页温小青; 回顾2024年,红海危机、中东动荡加剧、俄乌冲突等地缘政治因素对全球LNG贸易产生了不同程度的影响;全球经济对LNG运输市场的影响呈现出区域性差异,亚洲需求增长与欧洲需求下降并存;全球液化产能仅增长2.5%,LNG船队规模大幅扩张,LNG即期...; 关键词：LNG运输 LNG运力 LNG供需 LNG液化产能国际LNG

有氧运动调控lnc-ORA对小鼠脂肪生成及胰岛素抵抗的作用与机制研究: 《中国运动医学杂志》2025年第2期128-138,共11页赵晋枫闫佩润王亚鑫贾迎秀曾雨; 国家自然科学基金(31500962);山西省科技厅基础研究计划项目(202103021224022)。; 目的:探究有氧运动对高脂饮食小鼠脂肪生成及胰岛素抵抗(insulin resistance,IR)的影响,以及有氧运动调控肥胖相关长链非编码RNA(obesity-related long noncoding RNA,lnc-ORA)在上述过程中的作用机制。方法:36只8周龄雄性C57BL/6J小鼠...; 关键词：有氧运动 lnc-ORA/PPARγ 脂肪生成 IRS-1/PI3K/AKT/GLUT4轴 IR

浅析停业营销对加油站客户流失率的影响——基于ln回归模型的实证分析: 《中国集体经济》2025年第6期118-121,共4页俞跃周; 文章以中石化油品销售A公司57座加油站停业改造为背景,分析停业期内实施停业营销与站点客户流失率之间的关系。基于其中11座已实施活动站点的数据,通过因素分析、ln函数构建回归模型等方法,探讨发券时长、发券组合对不同站点客户流失率...; 关键词：加油站停业营销客户流失率电子优惠券

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