外伤性脑梗死患者病情与血浆超敏C反应蛋白和白介素-6的关系分析  

Analgsis of the relationship between the early state of illness and serum C-reaction protein and interleukin-6in patients with traumatic cerebral infarction

作　　者：宋宇[1] 

机构地区：[1]南阳医学高等专科学校第一附属医院神经外科,南阳473058

出　　处：《中国实用神经疾病杂志》2013年第17期15-17,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨外伤性脑梗死患者早期病情与血浆超敏C反应蛋白及白介素-6的关系。方法 47例外伤性脑梗死患者被视为脑外伤组,而同期40例无神经系统疾病史的健康人群被视为正常对照组,比较2组人群在3h、6h、12h、24h、48h、3d和7d各时间点血浆hs-CRP和IL-6水平的变化;脑外伤组患者根据NIHSS评分可分为轻型组和重型组,比较2组在上述时间点的血浆hs-CRP和IL-6水平的变化;脑外伤组患者根据预后情况可分为预后良好组和预后不良组,比较2组在上述时间点的血浆hs-CRP和IL-6水平的变化。结果脑外伤组患者在3h时血浆hs-CRP水平与对照组无差异,但在6h、12h、24h、48h、3d和7d时较对照组明显升高,脑外伤组患者血浆IL-6水平在各时间点均高于对照组;重型组患者血浆hsCRP和IL-6水平在12h、24h、48h、3d和7d时较轻型组明显升高;预后良好组和预后不良组之间血浆hs-CRP和IL-6水平差异不大。结论脑外伤患者血浆hs-CRP和IL-6水平明显升高,与病人病情呈正相关。Objective To investigate the relationship between the early state of illness and the levels of serum C-reaction protein(hs-CRP)and interleukin-6(IL-6)in patients with traumatic cerebral infarction.Methods Totally 47patients with traumatic cerebral infarction were considered as the traumatic brain injury group,40healthy people without nervous system diseases at the same time were considered as the control group,and the levels of serum hs-CRP and IL-6in two groups were compared at 3h,6h,12h,24h,48h,3dand 7dtime points.Patients with traumatic cerebral infarction were divided into the mild group and the severe group according to the NIHSS score,and the levels of serum hs-CRP and IL-6in two groups were compared at the above time points.Patients with traumatic cerebral infarction were divided into the good prognosis group and the poor prognosis group according to the prognosis condition,and the levels of serum hs-CRP and IL-6in two groups were compared at the above time points.Results The level of serum hs-CRP in the traumatic brain injury group had no significant difference at 3hand were higher than that at 6h,12h,24h,48h,3dand 7dtime points compared with the control group;The level of serum IL-6in the traumatic brain injury group was higher than that at 3h,6h,12h,24h,48h,3dand 7dtime points compared with the control group.The levels of serum hs-CRP and IL-6in the severe group were higher than those in the mild group at 12h,24h,48h,3dand 7dtime points.The levels of serum hs-CRP and IL-6between the good prognosis group and the poor prognosis group had no significant difference.Conclusion The levels of serum hs-CRP and IL-6in patients with traumatic cerebral infarction obviously increase,which is positive correlation with the patient's condition.

关 键 词：外伤性脑梗死 C反应蛋白 白介素-6 

分 类 号：R743.33[医药卫生—神经病学与精神病学]