葡萄糖并胰岛素静脉输注对缺血性脑损害的保护作用  

Effect of intravenous infusion of glucose and insulin on patients with ischemic brain injury

作　　者：李惠珍[1] 崔兆文 陈丽萍[1] 

机构地区：[1]河北秦皇岛市北戴河医院,秦皇岛066100

出　　处：《中国实用神经疾病杂志》2013年第17期25-27,共3页Chinese Journal of Practical Nervous Diseases

基　　金：河北省科学技术厅资金资助项目(11276103D-52)

摘　　要：目的观察葡萄糖并胰岛素静脉输注对脑梗死患者预后的影响。方法将112例发病3d内的脑梗死患者以住院号最后一位数字的奇偶数随机分为治疗组(53例)和对照组(59例),分别给予葡萄糖+胰岛素静脉输注干预治疗和常规盐水作为溶媒治疗,治疗前和治疗后14d、28d均用(MMSE)美国国立卫生院卒中评分(NIHSS)评定患者的病情严重程度、简易精神状态量表(MMSE)评定患者的认知功能,头CT对比梗死体积(梗死体积采用Pullicino方法计算即病灶最大层面长轴×短轴×层面数×π/6)。结果治疗前治疗组与对照组NIHSS评分(24.50±1.29,25.25±1.71)、MMSE评分(15.75±1.50,16.25±1.50)、梗死体积[(11.03±0.82)mL3,(11.05±1.30)mL3)]差异无统计学意义(P>0.05),治疗14d、28d后治疗组较对照组NIHSS、梗死体积降低,差异有统计学意义(P<0.05),MMSE评分明显增高(P<0.001)。结论葡萄糖+胰岛素静脉输注患者神经功能缺损程度明显改善,对缺血性脑损害有保护作用。Objective To investigate effects of intravenous infusion of glucose and insulin on the prognosis of patients with cerebral infarction.Methods 112patients with cerebral infarction coming on 3days were randomly divided into the treatment group(53cases,treated with glucose plus insulin infusion therapy)and control group(59cases,treated with normal saline) according to the last digit of the odd and even number.NIHSS(American National Institutes of Health Stroke Scale,NIHSS) were used to evaluate the severity of disease,and MMSE(Mini-Mental State Examination)was used to evaluate the cognitive function 14days and 28days before and after treatment.The imaging head CT was made to contrast with infarct volume(infarct volume was calculated using the Pullicino method that length multiplied short axis levels multiplied level and multiplied number ofπ/6).Results The NIHSS,MMSE and infarct volume in the treatment group had no significant difference with these in the control group before treatment;The NIHSS and infarct volume in the treatment group was lower than these in the control group,however,the MMSE in the treatment group was higher than that in the control group 14days and 28days after treatment.Conclusion The glucose plus insulin infusion can obviously improve patients with neurological deficits and have a protective effect on ischemic brain damage.

关 键 词：脑梗死 葡萄糖胰岛素干预 脑保护 

分 类 号：R743.33[医药卫生—神经病学与精神病学]