1810例左、右半结肠癌临床病理分析  

Statistical analysis of clinicopathologic characteristics of 1810 cases between right-and left-sided colon cancer

作　　者：陈伟[1,2] 王贵玉[1,2] 陈瑛罡[1,2] 姜争[1,2] 刘正[1,2] 王猛[1,2] 王洪伟[1,2] 徐永鹏[1,2] 王锡山[1,2] 

机构地区：[1]哈尔滨医科大学附属第二医院结直肠肿瘤外科 [2]哈尔滨医科大学大肠癌研究所,150086

出　　处：《中华结直肠疾病电子杂志》2013年第4期162-165,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

摘　　要：目的通过研究左、右半结肠癌的临床及病理特征,探索其临床及生物学特性的区别,为后续开展的分子机制研究奠定基础。方法收集2001年1月至2010年12月在结直肠肿瘤外科,1810例经手术治疗结肠癌患者的临床及病理资料。其中男性984例,女性826例,平均年龄为59.7±11.9岁。右半结肠癌921例,占50.9%。应用卡方检验,对比分析左、右半结肠癌临床表型的区别。结果左、右半结肠癌在年龄(χ2=11.4792,P<0.01)、性别(χ2=6.8361,P<0.01)、大体型态(χ2=4.7157,P<0.05)、T分期(P<0.01)、病理类型(χ2=40.9880,P<0.01)、病理分化(χ2=25.4816,P<0.01)、淋巴结切除数(χ2=85.5153,P<0.01)中存在显著统计学差异。其中右半结肠癌患者中年龄组小于50岁和大于69岁发病率高;女性较男性多发;病理分期较晚的患者中粘液腺癌和印戒细胞癌多见。结论左、右半结肠癌在临床及生物学特性间存在差异,表明左、右半结肠癌可能为不同性质的肿瘤,存在不同的致癌机制。Objective By comparing the clinicopathologic characteristics of right-and left-sided colon cancer,find out the clinical and biological differences between them and lay the foundation for the following study of the molecular mechanisms .Methods All clinical data were from the department of colorectal cancer of The Second Affiliated Hospital of Harbin Medical University .The patients with colorectal cancer(CRC)were treated with surgery during January 2001 to December 2010.There were 1810 cases with colonic cancer including 984 males and 826 females.The mean age was 59.7 ±11.9 years.The proportion of right-sided colon cancer was 50 .9%.We compared the clinical differences of right and left colon cancer . Results Statistical analysis demonstrated that age ,gender,histology,morphological appearance ,T stage and the number of lymph nodes dissection had significant correlation with anatomic location .The proportion of right-sided colon cancer was relatively high in patients aged less than 50 years(51.8%)and more than 69 years(57.6%).Patients with right-sided colon cancer were more likely to be women ,to be diagnosed with a more advanced stage , and to have more poorly differentiated tumors .Conclusions Different clinical and biological characteristics between right and left colon cancer were revealed .It demonstrated that right-and left-sided colon cancer may have a different carcinogenic mechanisms .

关 键 词：结肠肿瘤 肿瘤 各部位 病理学 临床 

分 类 号：R735.35[医药卫生—肿瘤]