我国眼表重建手术的特点和问题  

Features and problems of ocular surface reconstruction in China

作　　者：谢立信[1] 

机构地区：[1]山东省眼科研究所山东省眼科学重点实验室省部共建国家重点实验室培育基地,青岛266071

出　　处：《中华眼科医学杂志（电子版）》2011年第1期3-7,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

摘　　要：眼表疾病(OSD)是眼科界面临的棘手疾病之一。眼表疾病主要因角膜缘干细胞的破坏所致,角膜缘干细胞缺损常导致角膜上皮缺损、角膜新生血管化、角膜结膜化、角膜的溃疡及自溶等,重症者引起患者睑球粘连,结膜囊闭锁,严重影响美容,有的甚至失明。近年来,随着角膜缘干细胞理论的完善以及组织工程领域技术的发展,对眼表疾病治疗也有了较大进展。眼表重建手术是治疗眼表疾病的重要手段,而干细胞移植则是眼表重建手术中的关键因素。本文对我国眼表重建手术的特点和科学问题进行分析,并对存在的问题进行讨论。Ocular surface disease remains one of the challenges for ophthalmologists. The main cause of the disease is corneal limbal stem cell deficiency, which may result in epithelial defect,neovascularization,epithelialization,ulcer and autolysis in cornea,symblepharon,anophthalmos,and even blindness. With the development of corneal limbal stem cell theory and tissue engineering techniques, management of ocular surface disease has been greatly improved in recent years. Ocular surface reconstruction has become a major therapeutic approach,the key of which is stem cell transplantation. The surgical features and related scientific issues were evaluated in this article.

关 键 词：眼表重建术 角膜缘干细胞 移植 

分 类 号：R779.6[医药卫生—眼科]