生长抑素瘤的临床病理特征与诊治分析  

Clinicopathologic features, diagnosis and treatment of somatostatinoma

作　　者：陈泓磊[1] 陈创奇[1] 马晋平[1] 蔡世荣[1] 何裕隆[1] 崔冀[1] 

机构地区：[1]中山大学附属第一医院胃肠胰外科,中山大学胃癌诊治研究中心,广州510080

出　　处：《消化肿瘤杂志（电子版）》2012年第2期112-115,共4页Journal of Digestive Oncology(Electronic Version)

摘　　要：目的探讨生长抑素瘤的临床病理特征及诊治。方法回顾分析中山大学附属第一医院胃肠胰外科收治的2例患者及国内文献报道的5例生长抑素瘤患者的临床病理资料。结果 7例患者(男2例,女5例)年龄22～72岁,平均43.0岁。临床表现腹痛4例,腹泻3例,腹部包块1例,低血糖1例。误诊为其他肿瘤4例,包括胰岛细胞瘤2例,胰腺囊腺瘤1例,十二指肠类癌1例。6例患者行手术切除肿瘤,1例患者行活检术,术后病理确诊为生长抑素瘤,免疫组化生长抑素(SS)表达均阳性。结论生长抑素瘤临床罕见,术前易误诊,确诊需靠术后病理组织学检查;完整切除原发肿瘤及转移灶是本病最有效的治疗方法。Objective To study the clinicopathologic features , diagnosis and treatment of somatostatinoma. Method Clinicopathologic data of 7 patients with somatostatinoma were analyzed retrospectively, two cases from the First Affiliated Hospital of Sun Yat-sen University , the other from the Chinese literatures. Results The mean age of all 7 patients (2 men, 5 women) was 43.0 (range 22 ～ 72). The main symptoms including abdominal pain in 4 cases , diarrhea in 3, abdominal mass and hypoglycemia respectively in one case. Four cases were misdiagnosed as other tumors , including 2 insulinomas, one pancreatic cystadenoma and duodenal carcinoid respectively. Six cases received surgical resection and the other one received only surgical biopsy. The diagnosis of somatostatinoma was confirmed by postoperative pathology with positive immunohistochemical staining of somatostatin (SS). Conclusions Somatostatinoma is a rare kind of malignant tumor. The rate of misdiagnosis is very high because of atypical clinical manifestations. Correct diagnosis depends on histopathologic examination. Complete resection of primary tumor and metastases is the most effective treatment.

关 键 词：生长抑素瘤 免疫组织化学 诊断 治疗 

分 类 号：R735[医药卫生—肿瘤]