52例青年胃癌患者临床病理特点和预后分析  

Clinicopathological characteristics and prognosis analysis of gastric cancer in young patients

作　　者：吴伍林[1] 刁飞宇[2] 吴德庆[1] 蔡观福[1] 陈仕荣[1] 

机构地区：[1]广东省人民医院普通外科,广州510080 [2]中山大学附属第二医院外科

出　　处：《消化肿瘤杂志（电子版）》2012年第4期245-249,共5页Journal of Digestive Oncology(Electronic Version)

摘　　要：目的了解青年胃癌的临床病理特点,探讨影响青年胃癌患者的预后因素。方法回顾性分析2000年至2007年间52例40岁以下的青年胃癌患者,比较其与同期非青年胃癌患者的临床病理特点和预后,分析本组青年胃癌患者预后的影响因素。结果青年胃癌患者以女性多发常见;与非青年胃癌患者相比,组织分型、大体类型较差,进展期胃癌患者常见,根治手术切除率较低。青年组胃癌患者总体5年生存率为36.9%,显著低于非青年胃癌患者的46.1%,根治术后两组5年生存率相仿,分别为47.1%和51.3%,差异无统计学意义。Cox多因素回归分析结果显示肿瘤部位、浸润深度和淋巴结转移是影响本组胃癌患者的独立预后因素。结论青年胃癌患者早期诊断率低,临床病理特点差,预后不佳。早期诊断,提高根治手术的机会是提高患者预后的关键。Objective To investigate the clinicopathologic characteristics and analyze the prognostic factors of gastric cancer in young patients.Methods Clinicopathological data of 52 gastric cancer patients under age of 40 years from 2000 to 2007 were analyzed retrospectively.The demographic,clinicopathologic characteristics and survival outcome were compared between the young gastric caner cases and older ones with age more than 40 years.The factors affecting the prognosis of young gastric cancer patients were analyzed.Results There were more female young gastric cancer patients,but no significant difference.Compared with the older group,the proportions of patients with worse Borrmann types,poorly-differentiated types and advanced stages were significantly higher in the young group(P<0.05).The radical resection rate was 73.1% in the young group,significantly lower than 85.7% in the older group(P <0.05).The overall 5-year survival rate was 36.9% in the young group,significantly lower than 46.1% in the older group(P<0.05).However,the 5-year survival rates of the patients with radical resection in the two groups were 47.1% and 51.3% respectively,no significant difference was found.Cox multivariate regression analysis revealed that tumor location,infiltrative depth and lymph node metastasis were independent prognostic factors for young gastric cancer patients.Conclusions The early detection rate of gastric cancer in young patients is low and clinicopathologic characteristics as well as survival outcome are worse than the older patients.Early diagnosis and radical resection are important to improve the better prognosis of such patients.

关 键 词：胃肿瘤 青年 临床病理 根治手术 生存预后 

分 类 号：R735.2[医药卫生—肿瘤]