^(18)F-FDGPET/CT在分化型甲状腺癌术后评价中的应用  

Application of ^(18)F-FDG PET/CT in monitoring recurrence and metastasis of differentiated thyroid cancer post operation

作　　者：魏丽晶[1] 丁勇[1] 宋人和[1] 于亚彬[1] 纵照义[1] 

机构地区：[1]军事医学科学院附属医院核医学科,北京100071

出　　处：《功能与分子医学影像学（电子版）》2012年第2期84-87,共4页Functional and Molecular Medical Imaging(Electronic Edition)

摘　　要：目的探讨分化型甲状腺癌(DTC)术后,18F-FDGPET/CT在甲状腺癌复发及转移中的应用。方法 36例DTC术后合并131I治疗患者,分别行18FDGPET/CT全身显像及131I全身扫描(131I-WBS),同时检测患者血清甲状腺球蛋白(Tg)。结果 34例Tg阳性的患者中131I-WBS10例阳性,PET/CT显像19例阳性。2例Tg阴性的患者中131I-WBS和PET/CT显像均阴性。3例在131I-WBS中提示甲状腺肿瘤残存者,在PET/CT检查中均为阳性;7例在131I-WBS中提示淋巴结转移者,在PET/CT检查中均为阳性,在131I-WBS阴性患者中PET/CT显像发现6例肺转移患者及3例骨转移。结论 PET/CT和131I扫描在甲状腺残存及淋巴结转移的诊断中,两种检查大致相同,但PET/CT比131I扫描在诊断骨转移及肺转移中更具有优势,另外,PET/CT在Tg升高而131I-WBS阴性的病人中应用有很重要的意义。PET/CT尚可发现其他良性及恶性病变,在DTC的再分期中有重要价值。Objective To evaluate the efficiency of 18F-FDG PET/CT in detecting metastasis of differentiated thyroid cancer(DTC) post operation.Methods PET/CT whole body imaging and 131I whole body scan(131I-WBS) were performed in 36 patients with differentiated thyroid cancer post surgery and 131I therapy,and serum thyroglobulin(Tg) was measured simultaneously.Results There were 10 patients with positive 131I-WBS and 19 with positive PET/CT whole body imaging in 34 Tg-positive patients.Two Tg-negative patients had negative finding on both PET/CT whole body imaging and 131I-WBS.Three patients with remnant thyroid cancer and seven patients with lymph node metastasis revealed by 131I-WBS were confirmed by PET/CT whole body imaging.Among patients with negative finding on 131I-WBS,lung metastasis and bone metastasis were revealed by PET/CT imaging in 6 and 3 patients respectively.Conclusion Both PET/CT scan and 131I-WBS can effectively detect thyroid remnant and lymph node metastasis,but PET/CT is more sensitive in detecting lung and bone metastases.In addition,PET/CT is very important in the Tg-positive and 131I whole body scan-negative patients.PET/CT scan can also find other benign and malignant lesions.18F-FDG PET/CT is useful in the re-staging diagnosis of differentiated thyroid cancer.

关 键 词：分化型甲状腺癌 131I全身显像 体层摄影术 发射型计算机 体层摄影术 X线计算机 脱氧葡萄糖 甲状腺球蛋白 

分 类 号：R736.1[医药卫生—肿瘤]