CLINICAL RESEARCH ON BAMBUTEROL SOLUTION AND TABLET  

作　　者：张希龙 夏锡荣 施毅 郑培德 

机构地区：[1]Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,China [2]Nanjing General Hospital PLA, Nanjing 210002, China [3]Gulou Hospital Nanjing 210008, China

出　　处：《China Medical Abstracts(Internal Medicine)》2003年第3期185-189,共5页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To evaluate the efficacy and safety of a new long-acting β2 agonist hydrochloric bambuterol for treating asthma.Methods Using randomized, single-blind control and open trials, 254 patients were divided into three groups: treatment group (100 cases), control group(50 cases) and open group(104 cases) .The treatment group and the open group were further divided into two subgroups (tablet group and solution group) and were treated with either bambuterol tablet or solution at a dose of 10-20mg, once daily in the evening for 4 weeks and meanwhile dose titration was undertaken.Results The clinical control percentages were 54%, 46% and 49.07%, 62.75%, and the efficacy percentages were 88%, 94% and 92.4%, 92.17% respectively in the treatment subgroups and open subgroups. The lung function had been significantly improved at the end of 2 weeks’ treatment. The dose titration suggests that the proper dose may be 20mg/ day for some asthmatic patients. The incidence of adverse effects was 7.77% in tabletObjective To evaluate the efficacy and safety of a new long-acting β2 agonist hydrochloric bambuterol for treating asthma.Methods Using randomized, single-blind control and open trials, 254 patients were divided into three groups: treatment group (100 cases), control group(50 cases) and open group(104 cases) .The treatment group and the open group were further divided into two subgroups (tablet group and solution group) and were treated with either bambuterol tablet or solution at a dose of 10-20mg, once daily in the evening for 4 weeks and meanwhile dose titration was undertaken.Results The clinical control percentages were 54%, 46% and 49.07%, 62.75%, and the efficacy percentages were 88%, 94% and 92.4%, 92.17% respectively in the treatment subgroups and open subgroups. The lung function had been significantly improved at the end of 2 weeks’ treatment. The dose titration suggests that the proper dose may be 20mg/ day for some asthmatic patients. The incidence of adverse effects was 7.77% in tablet group and 5.94% in solution group. The main side-effects were mild tremor, palpitation and dizziness and they didn’ t interrupt the treatment.Conclusion Hydrochloric bambuterol is a safe and effective long-acting bronchodilator.

关 键 词：asthma SUBGROUPS tablet EVENING AGONIST COUGH titration expiratory hydrochloric treating 

分 类 号：R562.25[医药卫生—呼吸系统]